David C S Roberts
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Explore the profile of David C S Roberts including associated specialties, affiliations and a list of published articles.
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65
Citations
2148
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Recent Articles
1.
Roberts D, Zimmer B
Psychopharmacology (Berl)
. 2020 May;
237(9):2685-2693.
PMID: 32468100
Rationale: Virtually all cocaine self-administration studies have used a "unit dose" as a reinforcing stimulus; the subject is a passive recipient of an experimenter-selected dose. Objectives: The present experiments examined...
2.
Allain F, Roberts D, Levesque D, Samaha A
Neuropharmacology
. 2017 Feb;
117:227-237.
PMID: 28137451
The choice between smoking, injecting or swallowing a drug influences the risk of addiction, as this determines both how much drug gets into the brain and how fast. Most animal...
3.
Allain F, Minogianis E, Roberts D, Samaha A
Neurosci Biobehav Rev
. 2015 Jun;
56:166-79.
PMID: 26116543
How much, how often and how fast a drug reaches the brain determine the behavioural and neuroplastic changes associated with the addiction process. Despite the critical nature of these variables,...
4.
Young K, Franklin T, Roberts D, Jagannathan K, Suh J, Wetherill R, et al.
J Neurosci
. 2014 Apr;
34(14):5038-43.
PMID: 24695721
Relapse is a widely recognized and difficult to treat feature of the addictions. Substantial evidence implicates cue-triggered activation of the mesolimbic dopamine system as an important contributing factor. Even drug...
5.
Zimmer B, Chiodo K, Roberts D
Psychopharmacology (Berl)
. 2013 Oct;
231(5):949-54.
PMID: 24146137
Rationale: Continuous administration of D-amphetamine has shown promise as a treatment for psychostimulant addiction. In rodent studies, constant infusion of D-amphetamine (5 mg/kg/day) has been shown to reduce cocaine-reinforced responding...
6.
Crawford J, Roberts D, Beveridge T
Drug Alcohol Depend
. 2013 Aug;
132(3):414-9.
PMID: 23953655
Background: Given the problems associated with the escalation in methamphetamine (METH) use, the identification of more effective treatment strategies is essential. Group II metabotropic glutamate receptors (mGluRs) have been suggested...
7.
Ferris M, Calipari E, Melchior J, Roberts D, Espana R, Jones S
Eur J Neurosci
. 2013 Jun;
38(4):2628-36.
PMID: 23725404
There is great interest in outlining biological factors and behavioral characteristics that either predispose or predict vulnerability to substance use disorders. Response to an inescapable novel environment has been shown...
8.
Calipari E, Ferris M, Zimmer B, Roberts D, Jones S
Neuropsychopharmacology
. 2013 May;
38(12):2385-92.
PMID: 23719505
The dopamine transporter (DAT) is responsible for terminating dopamine (DA) signaling and is the primary site of cocaine's reinforcing actions. Cocaine self-administration has been shown previously to result in changes...
9.
Roberts D, Gabriele A, Zimmer B
Neurosci Biobehav Rev
. 2013 May;
37(9 Pt A):2026-36.
PMID: 23669047
IV drug self-administration is a special case of an operant task. In most operant experiments, the instrumental response that completes the schedule requirement is separate and distinct from the consumptive...
10.
Blume L, Bass C, Childers S, Dalton G, Roberts D, Richardson J, et al.
J Neurochem
. 2013 Jan;
124(6):808-20.
PMID: 23286559
Although biochemical and physiological evidence suggests a strong interaction between striatal CB1 cannabinoid (CB1 R) and D2 dopamine (D2 R) receptors, the mechanisms are poorly understood. We targeted medium spiny...