David B Martignetti
Overview
Explore the profile of David B Martignetti including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
10
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0
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Recent Articles
1.
da Costa A, Somuncu O, Ravindranathan R, Mukkavalli S, Martignetti D, Nguyen H, et al.
Cancer Res
. 2024 Jun;
84(20):3435-3446.
PMID: 38885312
Recent studies suggest that PARP and POLQ inhibitors confer synthetic lethality in BRCA1-deficient tumors by accumulation of single-stranded DNA (ssDNA) gaps at replication forks. Loss of USP1, a deubiquitinating enzyme,...
2.
Huffman B, Feng H, Parmar K, Wang J, Kapner K, Kochupurakkal B, et al.
Clin Cancer Res
. 2023 Oct;
29(24):5047-5056.
PMID: 37819936
Purpose: Combining gemcitabine with CHK1 inhibition has shown promise in preclinical models of pancreatic ductal adenocarcinoma (PDAC). Here, we report the findings from a phase I expansion cohort study (NCT02632448)...
3.
Rodriguez A, Epperly M, Filiatrault J, Velazquez M, Yang C, McQueen K, et al.
PLoS Genet
. 2022 Nov;
18(11):e1010459.
PMID: 36441774
Overexpression of the TGFβ pathway impairs the proliferation of the hematopoietic stem and progenitor cells (HSPCs) pool in Fanconi anemia (FA). TGFβ promotes the expression of NHEJ genes, known to...