David A Ostrov
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Explore the profile of David A Ostrov including associated specialties, affiliations and a list of published articles.
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111
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2511
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Recent Articles
1.
Park S, Park S, Seo S, Kwon H, Kim S, Kim S, et al.
World Allergy Organ J
. 2024 Apr;
17(5):100901.
PMID: 38638799
Background: Drug-induced hypersensitivity such as anaphylaxis is an important cause of drug-related morbidity and mortality. Cefaclor is a leading cause of drug induced type I hypersensitivity in Korea, but little...
2.
Berkowitz R, Bluhm A, Knox G, McCurdy C, Ostrov D, Norris M
Int J Mol Sci
. 2023 Nov;
24(21).
PMID: 37958703
The emergence of lethal coronaviruses follows a periodic pattern which suggests a recurring cycle of outbreaks. It remains uncertain as to when the next lethal coronavirus will emerge, though its...
3.
Shen Y, Voigt A, Goranova L, Abed M, Kleiner D, Maldonado J, et al.
JCI Insight
. 2023 Sep;
8(24).
PMID: 37676726
Sjögren's Disease (SjD) is a systemic autoimmune disease characterized by lymphocytic inflammation of the lacrimal and salivary glands (SG), dry eyes and mouth, and systemic symptoms. SARS-CoV-2 may trigger the...
4.
Park Y, Roach T, Soh S, Zeumer-Spataro L, Choi S, Ostrov D, et al.
J Immunol
. 2023 Jul;
211(5):727-734.
PMID: 37486226
Pre-B cell leukemia homeobox 1 (PBX1) controls chromatin accessibility to a large number of genes in various cell types. Its dominant negative splice isoform, PBX1D, which lacks the DNA and...
5.
Almutairi M, Lister A, Zhao Q, Line J, Adair K, Tailor A, et al.
J Immunol
. 2023 Mar;
210(8):1031-1042.
PMID: 36881872
Previous studies have shown that cysteine-reactive drug metabolites bind covalently with protein to activate patient T cells. However, the nature of the antigenic determinants that interact with HLA and whether...
6.
Berkowitz R, Ostrov D
Viruses
. 2023 Jan;
15(1).
PMID: 36680105
Evidence suggests that the N-terminal domain (NTD) of the SARS-CoV-2 spike protein interacts with host coreceptors that participate in viral entry. Resolving the identity of coreceptors has important clinical implications...
7.
Shen Y, Khatri B, Rananaware S, Li D, Ostrov D, Jain P, et al.
PLoS One
. 2023 Jan;
18(1):e0276700.
PMID: 36649279
COVID-19 is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The severity of COVID-19 is highly variable and related to known (e.g., age, obesity, immune deficiency) and unknown risk factors. The...
8.
Zhang X, Ostrov D, Tian H
Endocr Metab Immune Disord Drug Targets
. 2022 Dec;
23(9):1137-1150.
PMID: 36582067
Glucose, amino acids, and free fatty acids are critical nutrients participating in stimulating or regulating the hormone secretion of islets. These nutrients are believed to be metabolized by pancreatic endocrine...
9.
Shen Y, Voigt A, Goranova L, Abed M, Kleiner D, Maldonado J, et al.
medRxiv
. 2022 Nov;
PMID: 36324812
Objectives: Sjögren's Disease (SjD) is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration and the development of dry eyes and dry mouth resulting from the secretory dysfunction of...
10.
Brooks C, Ostrov D, Schumann N, Kakkad S, Li D, Pena K, et al.
Biochem Biophys Res Commun
. 2022 Sep;
630:57-63.
PMID: 36148729
The 2.6 Å crystal structure of the apo form of Hip1 (hydrolase important for pathogenesis) has been previously reported. However, very little is known about the active site architecture of...