David A Hinkle
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Explore the profile of David A Hinkle including associated specialties, affiliations and a list of published articles.
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15
Citations
397
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Recent Articles
1.
Moore A, Li J, Contag C, Currano L, Pyles C, Hinkle D, et al.
Sensors (Basel)
. 2024 Dec;
24(23).
PMID: 39686390
Freezing of gait (FOG) is a disabling yet poorly understood paroxysmal gait disorder affecting the vast majority of patients with Parkinson's disease (PD) as they reach advanced stages of the...
2.
Mullett S, Di Maio R, Greenamyre J, Hinkle D
J Mol Neurosci
. 2012 Oct;
49(3):507-11.
PMID: 23065353
DJ-1 deficiency is a cause of genetic Parkinson's disease (PARK7 PD). In sporadic Parkinson's disease (PD), however, DJ-1 is abundantly expressed in reactive astrocytes. This may represent a compensatory protective...
3.
Mullett S, Hinkle D
J Neurochem
. 2011 Jan;
117(3):375-87.
PMID: 21219333
Parkinson's disease (PD) brains show evidence of mitochondrial respiratory Complex I deficiency, oxidative stress, and neuronal death. Complex I-inhibiting neurotoxins, such as the pesticide rotenone, cause neuronal death and parkinsonism...
4.
Hinkle D, Mullett S, Gabris B, Hamilton R
Neuropathology
. 2010 May;
31(1):29-37.
PMID: 20497343
DJ-1, a protein that promotes the action of multiple anti-apoptotic/pro-survival pathways, is expressed prominently in human reactive astrocytes and in many human cancers. Glioblastomas (GBMs) are the most common adult...
5.
Mullett S, Hinkle D
Neurobiol Dis
. 2008 Oct;
33(1):28-36.
PMID: 18930142
Mutations that eliminate DJ-1 expression cause a familial form of Parkinson's disease (PD). In sporadic PD, and many other neurodegenerative diseases, reactive astrocytes over-express DJ-1 whereas neurons maintain its expression...
6.
Mullett S, Hamilton R, Hinkle D
Neuropathology
. 2008 Jul;
29(2):125-31.
PMID: 18647263
DJ-1 is a protein with anti-oxidative stress and anti-apoptotic properties that is abundantly expressed in reactive CNS astrocytes in chronic neurodegenerative disorders such as Parkinson's disease (PD), Alzheimer's disease (AD),...
7.
Bai Q, Mullett S, Garver J, Hinkle D, Burton E
Brain Res
. 2006 Sep;
1113(1):33-44.
PMID: 16942755
Loss-of-function mutations in the human PARK7 gene, encoding DJ-1, are a rare cause of autosomal recessive Parkinson's disease (ARPD). To facilitate generation of a novel vertebrate model, in which to...
8.
Hinkle D, Connor C
J Neurophysiol
. 2005 Jul;
94(4):2726-37.
PMID: 15987762
We performed a quantitative characterization of binocular disparity-tuning functions in the ventral (object-processing) pathway of the macaque visual cortex. We measured responses of 452 area V4 neurons to stimuli with...
9.
Davis J, Eberwine J, Hinkle D, Marciano P, Meaney D, McIntosh T
Neurochem Res
. 2004 Jun;
29(6):1113-21.
PMID: 15176468
Genomic microarrays are rapidly becoming ubiquitous throughout a wide variety of biological disciplines. As their use has grown during the past few years, many important discoveries have been made in...
10.
Swierczynski S, Lewis-Chambers S, Anderson J, Keller J, Hinkle D, Ali S
Acta Cytol
. 2004 Apr;
48(2):165-72.
PMID: 15085748
Objective: To examine the imprint of liquid-based technologies for cervicovaginal cytology on HIV-positive women, who are at high risk for cervical intraepithelial neoplasia. Study Design: We performed a retrospective search...