David A Flesher
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Explore the profile of David A Flesher including associated specialties, affiliations and a list of published articles.
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13
Citations
109
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Recent Articles
1.
Flesher D, Shin J, Debus R, Brudvig G
J Biol Chem
. 2025 Feb;
301(3):108272.
PMID: 39922494
Photosystem II (PSII) is the water-splitting enzyme of oxygenic photosynthesis. Using light energy, PSII catalytically oxidizes two water molecules to fuel downstream metabolism, forming an O-O bond and releasing O...
2.
Jiang H, Gisriel C, Cardona T, Flesher D, Brudvig G, Ho M
bioRxiv
. 2024 Nov;
PMID: 39553964
Thylakoid-free cyanobacteria are thought to preserve ancestral traits of early-evolving organisms capable of oxygenic photosynthesis. However, and until recently, photosynthesis studies in thylakoid-free cyanobacteria were only possible in the model...
3.
Flesher D, Liu J, Wang J, Gisriel C, Yang K, Batista V, et al.
J Biol Chem
. 2024 Jun;
300(7):107475.
PMID: 38879008
Photosystem II (PSII) is the water-plastoquinone photo-oxidoreductase central to oxygenic photosynthesis. PSII has been extensively studied for its ability to catalyze light-driven water oxidation at a MnCaO cluster called the...
4.
Gisriel C, Flesher D, Long Z, Liu J, Wang J, Bryant D, et al.
Photosynth Res
. 2023 Sep;
162(2-3):187-196.
PMID: 37749456
Chlorophylls and bacteriochlorophylls are the primary pigments used by photosynthetic organisms for light harvesting, energy transfer, and electron transfer. Many molecular structures of (bacterio)chlorophyll-containing protein complexes are available, some of...
5.
Gisriel C, Huang H, Reiss K, Flesher D, Batista V, Bryant D, et al.
BBA Adv
. 2023 May;
1:100024.
PMID: 37206888
[This corrects the article DOI: 10.1016/j.bbadva.2021.100019.].
6.
Gisriel C, Huang H, Reiss K, Flesher D, Batista V, Bryant D, et al.
BBA Adv
. 2023 Apr;
1:100019.
PMID: 37082022
Chlorophyll cofactors are vital for the metabolism of photosynthetic organisms. Cryo-electron microscopy (cryo-EM) has been used to elucidate molecular structures of pigment-protein complexes, but the minor structural differences between multiple...
7.
Gisriel C, Elias E, Shen G, Soulier N, Flesher D, Gunner M, et al.
Sci Adv
. 2023 Mar;
9(12):eadg0251.
PMID: 36961897
To compete in certain low-light environments, some cyanobacteria express a paralog of the light-harvesting phycobiliprotein, allophycocyanin (AP), that strongly absorbs far-red light (FRL). Using cryo-electron microscopy and time-resolved absorption spectroscopy,...
8.
Gisriel C, Shen G, Flesher D, Kurashov V, Golbeck J, Brudvig G, et al.
J Biol Chem
. 2022 Dec;
299(1):102815.
PMID: 36549647
Photosystem II (PSII) is the water-splitting enzyme central to oxygenic photosynthesis. To drive water oxidation, light is harvested by accessory pigments, mostly chlorophyll (Chl) a molecules, which absorb visible light...
9.
Wang J, Liu J, Gisriel C, Wu S, Maschietto F, Flesher D, et al.
J Struct Biol
. 2022 Oct;
214(4):107902.
PMID: 36202310
The atomic coordinates derived from cryo-electron microscopy (cryo-EM) maps can be inaccurate when the voxel scaling factors are not properly calibrated. Here, we describe a method for correcting relative voxel...
10.
Flesher D, Liu J, Wiwczar J, Reiss K, Yang K, Wang J, et al.
Photosynth Res
. 2022 Mar;
152(2):167-175.
PMID: 35322325
The oxygen-evolving complex (OEC) of photosystem II (PSII) cycles through redox intermediate states S (i = 0-4) during the photochemical oxidation of water. The S state involves an equilibrium of...