David A Egan
Overview
Explore the profile of David A Egan including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
36
Citations
2127
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
van der Velden L, Maas P, van Amersfoort M, Timmermans-Sprang E, Mensinga A, van der Vaart E, et al.
Front Endocrinol (Lausanne)
. 2022 Aug;
13:926210.
PMID: 35966052
Growth hormone (GH) and insulin-like growth factor-1 (IGF1) play an important role in mammalian development, cell proliferation and lifespan. Especially in cases of tumor growth there is an urgent need...
2.
Karantzelis N, Petropoulos M, De Marco V, Egan D, Fish A, Christodoulou E, et al.
Front Pharmacol
. 2022 May;
13:860682.
PMID: 35548337
DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential...
3.
Vernooij L, Bate-Eya L, Alles L, Lee J, Koopmans B, Jonus H, et al.
Mol Cancer Ther
. 2021 Apr;
20(6):1161-1172.
PMID: 33850004
Neuroblastoma tumors frequently overexpress the anti-apoptotic protein B-cell lymphoma/leukemia 2 (BCL-2). We previously showed that treating BCL-2-dependent neuroblastoma cells with the BCL-2 inhibitor venetoclax results in apoptosis, but unfortunately partial...
4.
Omta W, van Heesbeen R, Shen I, de Nobel J, Robers D, van der Velden L, et al.
SLAS Discov
. 2020 May;
25(6):655-664.
PMID: 32400262
There has been an increase in the use of machine learning and artificial intelligence (AI) for the analysis of image-based cellular screens. The accuracy of these analyses, however, is greatly...
5.
Argiriadi M, Benatuil L, Dubrovska I, Egan D, Gao L, Greischar A, et al.
BMC Mol Cell Biol
. 2019 Aug;
20(1):29.
PMID: 31382872
Background: CD40 is a 48 kDa type I transmembrane protein that is constitutively expressed on hematopoietic cells such as dendritic cells, macrophages, and B cells. Engagement of CD40 by CD40L...
6.
Wiggers C, Govers A, Lelieveld D, Egan D, Zwaan C, Sonneveld E, et al.
Pediatr Blood Cancer
. 2019 May;
66(8):e27785.
PMID: 31044544
Background: Acute myeloid leukemia (AML) is a heterogeneous disease regarding morphology, immunophenotyping, genetic abnormalities, and clinical behavior. The overall survival rate of pediatric AML is 60% to 70%, and has...
7.
Hobson A, Judge R, Aguirre A, Brown B, Cui Y, Ding P, et al.
J Med Chem
. 2018 Nov;
61(24):11074-11100.
PMID: 30384606
A HTS campaign identified compound 1, an excellent hit-like molecule to initiate medicinal chemistry efforts to optimize a dual ROCK1 and ROCK2 inhibitor. Substitution (2-Cl, 2-NH, 2-F, 3-F) of the...
8.
Roerink S, Sasaki N, Lee-Six H, Young M, Alexandrov L, Behjati S, et al.
Nature
. 2018 Apr;
556(7702):457-462.
PMID: 29643510
Every cancer originates from a single cell. During expansion of the neoplastic cell population, individual cells acquire genetic and phenotypic differences from each other. Here, to investigate the nature and...
9.
Gerlach J, Jordens I, Tauriello D, van t Land-Kuper I, Bugter J, Noordstra I, et al.
Proc Natl Acad Sci U S A
. 2018 Apr;
115(17):E3996-E4005.
PMID: 29632210
Wnt/β-catenin signaling controls development and adult tissue homeostasis by regulating cell proliferation and cell fate decisions. Wnt binding to its receptors Frizzled (FZD) and low-density lipoprotein-related 6 (LRP6) at the...
10.
Kruitwagen H, Westendorp B, Viebahn C, Post K, van Wolferen M, Oosterhoff L, et al.
Stem Cells Dev
. 2017 Nov;
27(2):133-146.
PMID: 29179659
Hepatic progenitor cells (HPCs) are adult liver stem cells that act as second line of defense in liver regeneration. They are normally quiescent, but in case of severe liver damage,...