David A Costantino
Overview
Explore the profile of David A Costantino including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
765
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0
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Recent Articles
1.
Steckelberg A, Vicens Q, Costantino D, Nix J, Kieft J
RNA
. 2020 Aug;
26(12):1767-1776.
PMID: 32848042
Exoribonuclease-resistant RNAs (xrRNAs) are discrete elements that block the progression of 5' to 3' exoribonucleases using specifically folded RNA structures. A recently discovered class of xrRNA is widespread in several...
2.
Yesselman J, Eiler D, Carlson E, Gotrik M, dAquino A, Ooms A, et al.
Nat Nanotechnol
. 2019 Aug;
14(9):866-873.
PMID: 31427748
RNA nanotechnology seeks to create nanoscale machines by repurposing natural RNA modules. The field is slowed by the current need for human intuition during three-dimensional structural design. Here, we demonstrate...
3.
Hartwick E, Costantino D, Macfadden A, Nix J, Tian S, Das R, et al.
Nat Commun
. 2018 Dec;
9(1):5074.
PMID: 30498211
Structured RNA elements, programmed RNA conformational changes, and interactions between different RNA domains underlie many modes of regulating gene expression, mandating studies to understand the foundational principles that govern these...
4.
Steckelberg A, Akiyama B, Costantino D, Sit T, Nix J, Kieft J
Proc Natl Acad Sci U S A
. 2018 Jun;
115(25):6404-6409.
PMID: 29866852
Folded RNA elements that block processive 5' → 3' cellular exoribonucleases (xrRNAs) to produce biologically active viral noncoding RNAs have been discovered in flaviviruses, potentially revealing a new mode of...
5.
Akiyama B, Laurence H, Massey A, Costantino D, Xie X, Yang Y, et al.
Science
. 2016 Dec;
354(6316):1148-1152.
PMID: 27934765
The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to understand the molecular processes of infection. Related flaviviruses produce noncoding subgenomic flaviviral RNAs (sfRNAs) that are linked...
6.
Colussi T, Costantino D, Zhu J, Donohue J, Korostelev A, Jaafar Z, et al.
Nature
. 2015 Feb;
519(7541):110-3.
PMID: 25652826
The central dogma of gene expression (DNA to RNA to protein) is universal, but in different domains of life there are fundamental mechanistic differences within this pathway. For example, the...
7.
Colussi T, Costantino D, Hammond J, Ruehle G, Nix J, Kieft J
Nature
. 2014 Jun;
511(7509):366-9.
PMID: 24909993
RNA is arguably the most functionally diverse biological macromolecule. In some cases a single discrete RNA sequence performs multiple roles, and this can be conferred by a complex three-dimensional structure....
8.
Chapman E, Costantino D, Rabe J, Moon S, Wilusz J, Nix J, et al.
Science
. 2014 Apr;
344(6181):307-10.
PMID: 24744377
Flaviviruses are emerging human pathogens and worldwide health threats. During infection, pathogenic subgenomic flaviviral RNAs (sfRNAs) are produced by resisting degradation by the 5'→3' host cell exonuclease Xrn1 through an...
9.
Zhu J, Korostelev A, Costantino D, Donohue J, Noller H, Kieft J
Proc Natl Acad Sci U S A
. 2011 Jan;
108(5):1839-44.
PMID: 21245352
Internal ribosome entry site (IRES) RNAs are elements of viral or cellular mRNAs that bypass steps of canonical eukaryotic cap-dependent translation initiation. Understanding of the structural basis of IRES mechanisms...
10.
Kieft J, Chase E, Costantino D, Golden B
RNA
. 2010 Apr;
16(6):1118-23.
PMID: 20410239
Although RNA molecules are highly negatively charged, anions have been observed bound to RNA in crystal structures. It has been proposed that anion binding sites found within isolated RNAs represent...