David A Barron
Overview
Explore the profile of David A Barron including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
4182
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0
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Recent Articles
1.
Samstein R, Lee C, Shoushtari A, Hellmann M, Shen R, Janjigian Y, et al.
Nat Genet
. 2019 Jan;
51(2):202-206.
PMID: 30643254
Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers, but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor mutational burden (TMB) may predict clinical...
2.
Zehir A, Benayed R, Shah R, Syed A, Middha S, Kim H, et al.
Nat Med
. 2017 Aug;
23(8):1004.
PMID: 28777785
No abstract available.
3.
Zehir A, Benayed R, Shah R, Syed A, Middha S, Kim H, et al.
Nat Med
. 2017 May;
23(6):703-713.
PMID: 28481359
Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable...
4.
Strand D, Liang Y, Yang F, Barron D, Ressler S, Schauer I, et al.
Am J Clin Exp Urol
. 2014 Nov;
2(3):239-48.
PMID: 25374926
Transforming Growth Factor-β (TGF-β) regulates the reactive stroma microenvironment associated with most carcinomas and mediates expression of many stromal derived factors important for tumor progression, including FGF-2 and CTGF. TGF-β...
5.
Kim W, Barron D, San Martin R, Chan K, Tran L, Yang F, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(46):16389-94.
PMID: 25313057
Myofibroblasts are a key cell type in wound repair, cardiovascular disease, and fibrosis and in the tumor-promoting microenvironment. The high accumulation of myofibroblasts in reactive stroma is predictive of the...
6.
Ressler S, Dang T, Wu S, Tse D, Gilbert B, Vyakarnam A, et al.
Am J Pathol
. 2014 Sep;
184(11):2951-64.
PMID: 25219356
WFDC1/ps20 is a whey acidic protein four-disulfide core member that exhibits diverse growth and immune-associated functions in vitro. In vivo functions are unknown, although WFDC1 is lower in reactive stroma....
7.
San Martin R, Barron D, Tuxhorn J, Ressler S, Hayward S, Shen X, et al.
Am J Pathol
. 2014 Apr;
184(6):1860-70.
PMID: 24713391
Reactive stroma co-evolves with cancer, exhibiting tumor-promoting properties. It is also evident at sites of wound repair and fibrosis, playing a key role in tissue homeostasis. The specific cell types...
8.
Barron D, Rowley D
Endocr Relat Cancer
. 2012 Aug;
19(6):R187-204.
PMID: 22930558
Reactive stroma initiates during early prostate cancer development and coevolves with prostate cancer progression. Previous studies have defined the key markers of reactive stroma and have established that reactive stroma...
9.
Barron D, Strand D, Ressler S, Dang T, Hayward S, Yang F, et al.
PLoS One
. 2010 Nov;
5(10):e13751.
PMID: 21060787
TGF-β1 is overexpressed in wound repair and in most proliferative disorders including benign prostatic hyperplasia and prostate cancer. The stromal microenvironment at these sites is reactive and typified by altered...