Author: Dattatray S Bhat

1.

Body Composition and Cardiometabolic Risk Markers in Children of Women who Took Part in a Randomized Controlled Trial of a Preconceptional Nutritional Intervention in Mumbai, India

Sahariah S, Gandhi M, Chopra H, Kehoe S, Johnson M, Di Gravio C, et al.

J Nutr . 2023 Mar; 152(4):1070-1081. PMID: 36967164

Background: Maternal nutrition influences fetal development and may permanently alter ("program") offspring body composition and metabolism, thereby influencing later risk of diabetes and cardiovascular (cardiometabolic) disease. The prevalence of cardiometabolic...

2.

Gains in body mass and body water in pregnancy and relationships to birth weight of offspring in rural and urban Pune, India

Rush E, Plank L, Lubree H, Bhat D, Ganpule A, Yajnik C

J Nutr Sci . 2022 Oct; 11:e75. PMID: 36304819

Maternal size, weight gain in pregnancy, fetal gender, environment and gestational age are known determinants of birth weight. It is not clear which component of maternal weight or gained weight...

3.

Circulating microRNAs from early childhood and adolescence are associated with pre-diabetes at 18 years of age in women from the PMNS cohort

Joglekar M, Kunte P, Wong W, Bhat D, Satoor S, Patil R, et al.

J Dev Orig Health Dis . 2022 Apr; 13(6):806-811. PMID: 35450554

With type 2 diabetes presenting at younger ages, there is a growing need to identify biomarkers of future glucose intolerance. A high (20%) prevalence of glucose intolerance at 18 years...

4.

Body Composition and Cardiometabolic Risk Markers in Children of Women who Took Part in a Randomized Controlled Trial of a Preconceptional Nutritional Intervention in Mumbai, India

Sahariah S, Gandhi M, Chopra H, Kehoe S, Johnson M, Di Gravio C, et al.

J Nutr . 2022 Jan; 152(4):1070-1081. PMID: 35015882

Background: Maternal nutrition influences fetal development and may permanently alter ("program") offspring body composition and metabolism, thereby influencing later risk of diabetes and cardiovascular (cardiometabolic) disease. The prevalence of cardiometabolic...

5.

Poor In Utero Growth, and Reduced β-Cell Compensation and High Fasting Glucose From Childhood, Are Harbingers of Glucose Intolerance in Young Indians

Yajnik C, Bandopadhyay S, Bhalerao A, Bhat D, Phatak S, Wagh R, et al.

Diabetes Care . 2021 Oct; 44(12):2747-2757. PMID: 34610922

Objective: India is a double world capital of early-life undernutrition and type 2 diabetes. We aimed to characterize life course growth and metabolic trajectories in those developing glucose intolerance as...

6.

Transient systemic inflammation in adult male mice results in underweight progeny

Rokade S, Upadhya M, Bhat D, Subhedar N, Yajnik C, Ghose A, et al.

Am J Reprod Immunol . 2021 Feb; 86(1):e13401. PMID: 33576153

Problem: While the testes represent an immune-privileged organ, there is evidence that systemic inflammation is accompanied by local inflammatory responses. We therefore examined whether transient systemic inflammation caused any inflammatory...

7.

Birth weight, childhood and adolescent growth and diabetes risk factors in 21-year-old Asian Indians: the Pune Children's Study

Kumaran K, Lubree H, Bhat D, Joshi S, Joglekar C, Yajnik P, et al.

J Dev Orig Health Dis . 2020 Aug; 12(3):474-483. PMID: 32753090

Our objective was to investigate associations of body size (birth weight and body mass index (BMI)) and growth in height, body fat (adiposity) and lean mass during childhood and adolescence,...

8.

Maternal B12, Folate and Homocysteine Concentrations and Offspring Cortisol and Cardiovascular Responses to Stress

Krishnaveni G, Veena S, Johnson M, Kumaran K, Jones A, Bhat D, et al.

J Clin Endocrinol Metab . 2020 Mar; 105(7). PMID: 32206806

Context: Imbalances in maternal 1-carbon nutrients (vitamin B12, folate) have been shown to be associated with higher offspring cardiometabolic risk markers in India. Objective: We examined the hypothesis that low...

9.

A physiological dose of oral vitamin B-12 improves hematological, biochemical-metabolic indices and peripheral nerve function in B-12 deficient Indian adolescent women

Yajnik C, Behere R, Bhat D, Memane N, Raut D, Ladkat R, et al.

PLoS One . 2019 Oct; 14(10):e0223000. PMID: 31600243

Background: Vitamin B-12 deficiency is often considered synonymous with pernicious anemia, a rare condition in which severe malabsorption of the vitamin requires high-dose parenteral treatment. In developing countries such as...

10.

Evaluation of tracer labelled methionine load test in vitamin B-12 deficient adolescent women

Bhat D, Gruca L, Bennett C, Katre P, Kurpad A, Yajnik C, et al.

PLoS One . 2018 May; 13(5):e0196970. PMID: 29795596

Background: Methionine loading test (MLT) has been used primarily to identify defects in transsulfuration of homocysteine in cystathionine beta synthase deficiency. It may not be as useful to evaluate remethylation...