Daryan Kempe
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Explore the profile of Daryan Kempe including associated specialties, affiliations and a list of published articles.
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Citations
199
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Recent Articles
1.
Lau D, Tang Y, Kenche V, Copie T, Kempe D, Jary E, et al.
ACS Chem Neurosci
. 2024 Aug;
15(18):3270-3285.
PMID: 39197832
α-Synuclein (αSyn) aggregates, detected in the biofluids of patients with Parkinson's disease (PD), have the ability to catalyze their own aggregation, leading to an increase in the number and size...
2.
Golo M, Newman P, Kempe D, Biro M
Biochem Soc Trans
. 2024 Jun;
52(3):1489-1502.
PMID: 38856041
The tumor microenvironment (TME) is a complex and dynamic ecosystem that adjoins the cancer cells within solid tumors and comprises distinct components such as extracellular matrix, stromal and immune cells,...
3.
English K, Kwan R, Holz L, McGuffog C, Krol J, Kempe D, et al.
Nat Commun
. 2024 Feb;
15(1):1261.
PMID: 38341416
While CD4 T cells are a prerequisite for CD8 T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating the transfer of CD4-help to intrahepatic CD8 T cells are unknown....
4.
Mazalo J, Tay S, Kempe D, Biro M
Biophys J
. 2024 Feb;
123(15):2328-2342.
PMID: 38327056
T cells migrate constitutively with a polarized morphology, underpinned by signaling compartmentalization and discrete cytoskeletal organizations, giving rise to a dynamic and expansive leading edge, distinct from the stable and...
5.
Newman P, Yip Q, Osteil P, Anderson T, Sun J, Kempe D, et al.
Adv Sci (Weinh)
. 2023 Mar;
10(15):e2204741.
PMID: 36998105
Multicellular patterning of stem-cell-derived tissue models is commonly achieved via self-organizing activities triggered by exogenous morphogenetic stimuli. However, such tissue models are prone to stochastic behavior, limiting the reproducibility of...
6.
Govendir M, Kempe D, Sianati S, Cremasco J, Mazalo J, Colakoglu F, et al.
Dev Cell
. 2022 Sep;
57(18):2237-2247.e8.
PMID: 36113483
Cytotoxic T lymphocytes (CTLs) lyse target cells by delivering lytic granules that contain the pore former perforin to the cytotoxic immunological synapse. Here, we establish that opposing cytoskeletal forces drive...
7.
Cavanagh H, Kempe D, Mazalo J, Biro M, Endres R
J R Soc Interface
. 2022 May;
19(190):20220081.
PMID: 35537475
T cells use sophisticated shape dynamics (morphodynamics) to migrate towards and neutralize infected and cancerous cells. However, there is limited quantitative understanding of the migration process in three-dimensional extracellular matrices...
8.
Ecker M, Schregle R, Kapoor-Kaushik N, Rossatti P, Betzler V, Kempe D, et al.
Elife
. 2022 Jan;
11.
PMID: 35050850
T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the...
9.
Geoghegan N, Evelyn C, Whitehead L, Pasternak M, McDonald P, Triglia T, et al.
Nat Commun
. 2021 Jun;
12(1):3620.
PMID: 34131147
Host membrane remodeling is indispensable for viruses, bacteria, and parasites, to subvert the membrane barrier and obtain entry into cells. The malaria parasite Plasmodium spp. induces biophysical and molecular changes...
10.
Galeano Nino J, Pageon S, Tay S, Colakoglu F, Kempe D, Hywood J, et al.
Elife
. 2020 Oct;
9.
PMID: 33046212
Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations...