Darshan S Chandrashekar
Overview
Explore the profile of Darshan S Chandrashekar including associated specialties, affiliations and a list of published articles.
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45
Citations
4303
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Recent Articles
1.
Rao A, Stosic M, Mohanty C, Suresh D, Wang A, Lee D, et al.
Front Oncol
. 2024 Sep;
14:1440836.
PMID: 39301555
Human papillomaviruses (HPV), most commonly HPV16, are associated with a subset of head and neck squamous cell carcinoma (HNSCC) tumors, primarily oropharyngeal carcinomas, with integration of viral genomes into host...
2.
Chandrashekar D, Afaq F, Karthikeyan S, Athar M, Shrestha S, Singh R, et al.
Neoplasia
. 2024 Sep;
57:101046.
PMID: 39241280
The bromodomain and extraterminal (BET) family of proteins show altered expression across various cancers. The members of the bromodomain (BRD) family contain epigenetic reader domains that bind to acetylated lysine...
3.
Bajpai P, Agarwal S, Afaq F, Al Diffalha S, Chandrashekar D, Kim H, et al.
J Exp Clin Cancer Res
. 2024 Jul;
43(1):192.
PMID: 38992681
Background: Treatment with regorafenib, a multiple-kinase inhibitor, to manage metastatic colorectal cancers (mCRCs) shows a modest improvement in overall survival but is associated with severe toxicities. Thus, to reduce regorafenib-induced...
4.
Kaur J, Chandrashekar D, Varga Z, Sobottka B, Janssen E, Gandhi K, et al.
Genes (Basel)
. 2023 Sep;
14(9).
PMID: 37761830
Purpose: Triple-negative breast cancer (TNBC) is a molecularly complex and heterogeneous breast cancer subtype with distinct biological features and clinical behavior. Although TNBC is associated with an increased risk of...
5.
Aron M, Chandrashekar D, Canete-Portillo S, Brimo F, Williamson S, Osunkoya A, et al.
Mod Pathol
. 2023 Sep;
36(12):100333.
PMID: 37717923
Nested urothelial carcinoma (NUC) and large nested urothelial carcinoma (LNUC) of the upper urinary tract are exceedingly rare. This has contributed to the paucity of information regarding their clinicopathological and...
6.
Chen F, Zhang Y, Chandrashekar D, Varambally S, Creighton C
Nat Commun
. 2023 Sep;
14(1):5637.
PMID: 37704602
Both proteome and transcriptome data can help assess the relevance of non-coding somatic mutations in cancer. Here, we combine mass spectrometry-based proteomics data with whole genome sequencing data across 1307...
7.
Moore K, Boitet L, Chandrashekar D, Traylor A, Esman S, Erman E, et al.
J Pharmacol Exp Ther
. 2023 Sep;
388(2):605-612.
PMID: 37699712
Arsenicals are deadly chemical warfare agents that primarily cause death through systemic capillary fluid leakage and hypovolemic shock. Arsenical exposure is also known to cause acute kidney injury, a condition...
8.
Monsivais D, Parks S, Chandrashekar D, Varambally S, Creighton C
Oncotarget
. 2023 May;
14:399-412.
PMID: 37141409
Gene-level associations obtained from mass-spectrometry-based cancer proteomics datasets represent a resource for identifying gene candidates for functional studies. When recently surveying proteomic correlates of tumor grade across multiple cancer types,...
9.
Agarwal S, Afaq F, Bajpai P, Behring M, Kim H, Varambally A, et al.
Mol Cancer Res
. 2023 Apr;
21(7):698-712.
PMID: 37067340
Implications: FDA-approved small-molecule inhibitors of EZH2 can indirectly target BZW2 and because BZW2 functions as an oncogene, these inhibitors could serve as therapeutic agents for colorectal cancer.
10.
Balagannavar G, Basavaraju K, Bajpai A, Davuluri S, Kannan S, S Srini V, et al.
Syst Biol Reprod Med
. 2023 Mar;
69(3):196-214.
PMID: 36883778
There is a need to understand the molecular basis of testes under Non-Obstructive Azoospermia (NOA), a state of failed spermatogenesis. There has been a lack of attention to the transcriptome...