Darryl S Pickering
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Explore the profile of Darryl S Pickering including associated specialties, affiliations and a list of published articles.
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95
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636
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Recent Articles
1.
Buschbom-Helmke S, Wang P, Alcaide A, Miguez-Cabello F, Carta M, Viotti J, et al.
J Med Chem
. 2024 Aug;
67(16):14524-14542.
PMID: 39133077
Twenty-one simplified analogues of the natural product domoic acid were designed, synthesized, and then characterized at homomeric kainic acid (KA) receptors (GluK1-3,5). displays a high affinity for homomeric GluK5 receptors...
2.
Bay Y, Cabello F, Koens C, Frantsen S, Pickering D, Frydenvang K, et al.
J Struct Biol
. 2024 Jul;
216(3):108113.
PMID: 39079583
Kainate receptors play an important role in the central nervous system by mediating postsynaptic excitatory neurotransmission and modulating the release of the inhibitory neurotransmitter GABA through a presynaptic mechanism. To...
3.
Bay Y, Egeberg Jeppesen M, Frydenvang K, Francotte P, Pirotte B, Pickering D, et al.
FEBS Lett
. 2024 Feb;
598(7):743-757.
PMID: 38369668
Kainate receptors belong to the family of ionotropic glutamate receptors and contribute to the majority of fast excitatory neurotransmission. Consequently, they also play a role in brain diseases. Therefore, understanding...
4.
Chalupnik P, Marek A, Hovah M, Pickering D, Temperini P, Donbosco S, et al.
J Labelled Comp Radiopharm
. 2024 Feb;
67(4):120-130.
PMID: 38332677
Kainate receptors play a crucial role in mediating synaptic transmission within the central nervous system. However, the lack of selective pharmacological tool compounds for the GluK3 subunit represents a significant...
5.
Bay Y, Venskutonyte R, Frantsen S, Thorsen T, Musgaard M, Frydenvang K, et al.
FEBS J
. 2023 Dec;
291(7):1506-1529.
PMID: 38145505
The kainate receptors GluK1-3 (glutamate receptor ionotropic, kainate receptors 1-3) belong to the family of ionotropic glutamate receptors and are essential for fast excitatory neurotransmission in the brain, and are...
6.
Francotte P, Bay Y, Goffin E, Colson T, Lesenfants C, Dorosz J, et al.
Eur J Med Chem
. 2023 Dec;
264:116036.
PMID: 38101041
The synthesis and biological evaluation on AMPA and kainate receptors of new examples of 3,4-dihydro-2H-1,2,4-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxides is described. The introduction of a cyclopropyl chain instead of an ethyl chain at...
7.
Chalupnik P, Vialko A, Pickering D, Nielsen B, Bay Y, Kristensen A, et al.
ChemMedChem
. 2023 Jun;
18(18):e202300278.
PMID: 37387321
Kainate receptors are a class of ionotropic glutamate receptors that respond to the excitatory neurotransmitter glutamate in the central nervous system and play an important role in the development of...
8.
Chalupnik P, Vialko A, Pickering D, Hinkkanen M, Donbosco S, Moller T, et al.
Int J Mol Sci
. 2022 Aug;
23(15).
PMID: 35955932
Kainate receptors belong to the family of glutamate receptors ion channels, which are responsible for the majority of rapid excitatory synaptic transmission in the central nervous system. The therapeutic potential...
9.
Poulie C, Larsen Y, Leteneur C, Barthet G, Bjorn-Yoshimoto W, Malhaire F, et al.
ACS Chem Neurosci
. 2022 Apr;
13(10):1580-1587.
PMID: 35475632
The development of tool compounds for the ionotropic glutamate receptors (iGluRs) remains an important research objective, as these are essential for the study and understanding of the roles of these...
10.
Frydenvang K, Pickering D, Kastrup J
J Physiol
. 2021 May;
600(2):181-200.
PMID: 33938001
This paper summarizes the present knowledge on how positive allosteric modulators (PAMs) interact with the ligand-binding domain (LBD) of AMPA and kainate receptors, based on structure determinations. AMPA and kainate...