Darren Grafham
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Explore the profile of Darren Grafham including associated specialties, affiliations and a list of published articles.
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10
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5417
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Recent Articles
1.
van Campen J, Sollars E, Thomas R, Bartlett C, Milano A, Parker M, et al.
Int J Neonatal Screen
. 2019 Dec;
5(4):40.
PMID: 31844782
Next generation DNA sequencing (NGS) has the potential to improve the diagnostic and prognostic utility of newborn screening programmes. This study assesses the feasibility of automating NGS on dried blood...
2.
Skinner B, Sargent C, Churcher C, Hunt T, Herrero J, Loveland J, et al.
Genome Res
. 2015 Nov;
26(1):130-9.
PMID: 26560630
We have generated an improved assembly and gene annotation of the pig X Chromosome, and a first draft assembly of the pig Y Chromosome, by sequencing BAC and fosmid clones...
3.
Howe K, Clark M, Torroja C, Torrance J, Berthelot C, Muffato M, et al.
Nature
. 2013 Apr;
496(7446):498-503.
PMID: 23594743
Zebrafish have become a popular organism for the study of vertebrate gene function. The virtually transparent embryos of this species, and the ability to accelerate genetic studies by gene knockdown...
4.
Church D, Schneider V, Graves T, Auger K, Cunningham F, Bouk N, et al.
PLoS Biol
. 2011 Jul;
9(7):e1001091.
PMID: 21750661
No abstract available.
5.
Boles M, Wilkinson B, Wilming L, Liu B, Probst F, Harrow J, et al.
PLoS Genet
. 2009 Dec;
5(12):e1000759.
PMID: 20011118
An accurate and precisely annotated genome assembly is a fundamental requirement for functional genomic analysis. Here, the complete DNA sequence and gene annotation of mouse Chromosome 11 was used to...
6.
7.
Chapman M, Donaldson I, Gilbert J, Grafham D, Rogers J, Green A, et al.
Genome Res
. 2004 Jan;
14(2):313-8.
PMID: 14718377
Comparative analysis of genomic sequences is becoming a standard technique for studying gene regulation. However, only a limited number of tools are currently available for the analysis of multiple genomic...
8.
Chapman M, Charchar F, Kinston S, Bird C, Grafham D, Rogers J, et al.
Genomics
. 2003 Mar;
81(3):249-59.
PMID: 12659809
Comparative genomic sequence analysis is a powerful technique for identifying regulatory regions in genomic DNA. However, its utility largely depends on the evolutionary distances between the species involved. Here we...
9.
Waterston R, Lindblad-Toh K, Birney E, Rogers J, Abril J, Agarwal P, et al.
Nature
. 2002 Dec;
420(6915):520-62.
PMID: 12466850
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report...
10.
Gottgens B, Barton L, Chapman M, Sinclair A, Knudsen B, Grafham D, et al.
Genome Res
. 2002 May;
12(5):749-59.
PMID: 11997341
The stem cell leukemia (SCL) gene encodes a bHLH transcription factor with a pivotal role in hematopoiesis and vasculogenesis and a pattern of expression that is highly conserved between mammals...