Darren C Holland
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Explore the profile of Darren C Holland including associated specialties, affiliations and a list of published articles.
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22
Citations
50
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Recent Articles
1.
Zdouc M, Blin K, Louwen N, Navarro J, Loureiro C, Bader C, et al.
Nucleic Acids Res
. 2024 Dec;
53(D1):D678-D690.
PMID: 39657789
Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is...
2.
Holland D, Prebble D, Calcott M, Schroder W, Ferretti F, Lock A, et al.
Molecules
. 2024 Aug;
29(15).
PMID: 39125052
Marine natural products (MNPs) continue to be tested primarily in cellular toxicity assays, both mammalian and microbial, despite most being inactive at concentrations relevant to drug discovery. These MNPs become...
3.
Kumar P, Wallis M, Zhou X, Li F, Holland D, Reddell P, et al.
J Nat Prod
. 2024 Jul;
87(7):1817-1825.
PMID: 38964296
Our ongoing exploration of Australian rainforest plants for the biodiscovery of anti-inflammatory agents led to the isolation and structural elucidation of eight new arylalkenyl α,β-unsaturated-δ-lactones, triplinones A-H (), from the...
4.
Holland D, Hayton J, Kiefel M, Carroll A
Molecules
. 2024 Jun;
29(12).
PMID: 38930871
Synthetic efforts toward complex natural product (NP) scaffolds are useful ones, particularly those aimed at expanding their bioactive chemical space. Here, we utilised an orthogonal cheminformatics-based approach to predict the...
5.
Love A, Purdy T, Hubert F, Kirwan E, Holland D, Moore B
ACS Synth Biol
. 2024 Mar;
13(4):1343-1354.
PMID: 38459634
Production of phytocannabinoids remains an area of active scientific interest due to the growing use of cannabis by the public and the underexplored therapeutic potential of the over 100 minor...
6.
Holland D, Carroll A
Molecules
. 2024 Feb;
29(3).
PMID: 38338339
NMR fingerprints are valuable tools for analyzing complex natural product mixtures and identifying incorrectly assigned structures in the literature. Our diagnostic NMR fingerprints for formyl phloroglucinol meroterpenoids revealed discrepancies in...
7.
Tang K, Zhao Y, Tao X, Li J, Chen Y, Holland D, et al.
J Nat Prod
. 2023 Oct;
86(11):2592-2619.
PMID: 37856864
Catecholamines (CAs) are aromatic amines containing a 3,4-dihydroxyphenyl nucleus and an amine side chain. Representative CAs included the endogenous neurotransmitters epinephrine, norepinephrine, and dopamine. CAs and their derivatives are good...
8.
Prebble D, Holland D, Ferretti F, Hayton J, Avery V, Mellick G, et al.
J Nat Prod
. 2023 Aug;
86(9):2171-2184.
PMID: 37610242
Amyloid protein aggregates are linked to the progression of neurodegenerative conditions and may play a role in life stages of , the parasite responsible for malaria. We hypothesize that amyloid...
9.
Holland D, Schroder W, Calcott M, Kaemmerer E, Avery V, Ekins M, et al.
J Nat Prod
. 2023 Aug;
86(9):2216-2227.
PMID: 37609780
Six new thiazole-containing cyclic peptides, the cyclotheonellazoles D-I (-), were isolated from the Australian marine sponge sp. (2131) with their structures assigned by comprehensive 1D and 2D NMR spectroscopic and...
10.
Daus M, Hayton J, Holland D, Voravuthikunchai S, Carroll A, Chakthong S
J Nat Prod
. 2023 Aug;
86(8):1994-2005.
PMID: 37578330
Three new bis-formyl phloroglucinol-meroterpenoids (-), three new euglobal type formyl phloroglucinol-meroterpenoids (-), and one new dimeric formyl phloroglucinol () were isolated from the leaves of . Camaldulensal A () is...