Darrell A Austin
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Explore the profile of Darrell A Austin including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
224
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Recent Articles
1.
Furukawa M, Ebmeyer J, Pak K, Austin D, Melhus A, Webster N, et al.
Infect Immun
. 2007 Feb;
75(5):2562-71.
PMID: 17325051
Mucosal hyperplasia is a characteristic component of otitis media. The present study investigated the participation of signaling via the Jun N-terminal protein kinase (JNK) mitogen-activated protein kinase in middle ear...
2.
Liu F, Ruiz M, Austin D, Webster N
Mol Endocrinol
. 2005 May;
19(8):2074-85.
PMID: 15878957
Chronic GnRH treatment causes homologous desensitization by reducing GnRH receptor and Gq/11 expression and by down-regulating protein kinase C (PKC), cAMP, and calcium-dependent signaling. It also causes heterologous desensitization of...
3.
Pirrung M, Liu Y, Deng L, Halstead D, Li Z, May J, et al.
J Am Chem Soc
. 2005 Mar;
127(13):4609-24.
PMID: 15796526
The principle of methyl scanning is proposed for determination of the sites of interaction between biologically active small molecules and their macromolecular target(s). It involves the systematic preparation of a...
4.
Liu F, Austin D, Webster N
Endocrinology
. 2003 Sep;
144(10):4354-65.
PMID: 12960037
Sustained exposure of gonadotropes to GnRH causes a pronounced desensitization of gonadotropin release, but the mechanisms involved are poorly understood. It is known that desensitization is associated with decreased GnRH...
5.
Kayali A, Austin D, Webster N
Endocrinology
. 2002 Sep;
143(10):3884-96.
PMID: 12239100
There is increasing evidence that protein kinase C (PKC) isoforms modulate insulin-signaling pathways in both positive and negative ways. Recent reports have indicated that the novel PKCdelta mediates some of...
6.
Liu F, Usui I, Evans L, Austin D, Mellon P, Olefsky J, et al.
J Biol Chem
. 2002 Jun;
277(35):32099-108.
PMID: 12050161
The hypothalamic hormone gonadotropin-releasing hormone (GnRH) stimulates the synthesis and release of the pituitary gonadotropins. GnRH acts through a plasma membrane receptor that is a member of the G protein-coupled...
7.
Vasilyev V, Pernasetti F, Rosenberg S, Barsoum M, Austin D, Webster N, et al.
Endocrinology
. 2002 Apr;
143(5):1651-9.
PMID: 11956146
GnRH regulates gonadotrope cells through GnRH receptor activation of the PKC-, MAPK-, and calcium-activated signaling cascades. Due to the paucity of homologous model systems expressing FSHbeta, little is known about...
8.
Liu F, Austin D, Mellon P, Olefsky J, Webster N
Mol Endocrinol
. 2002 Mar;
16(3):419-34.
PMID: 11875099
GnRH acts on pituitary gonadotropes to stimulate the synthesis and release of LH and FSH. However, the signaling pathways downstream of the GnRH receptor that mediate these effects are not...
9.
Eichhorn J, Kayali A, Resor L, Austin D, Rose D, Webster N
Endocrinology
. 2002 Jan;
143(2):655-64.
PMID: 11796522
Previously, we had shown that inhibition of PLC activity impaired the ability of insulin to activate ERK in 3T3-L1 adipocytes. In this study, we confirmed that the insulin receptor and...