Dario A A Vignali
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Explore the profile of Dario A A Vignali including associated specialties, affiliations and a list of published articles.
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196
Citations
19678
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Recent Articles
11.
Ngiow S, Manne S, Huang Y, Azar T, Chen Z, Mathew D, et al.
Cell
. 2024 Aug;
187(16):4336-4354.e19.
PMID: 39121847
Exhausted CD8 T (T) cells in chronic viral infection and cancer have sustained co-expression of inhibitory receptors (IRs). T cells can be reinvigorated by blocking IRs, such as PD-1, but...
12.
Grebinoski S, Pieklo G, Zhang Q, Visperas A, Cui J, Goulet J, et al.
J Immunol
. 2024 Aug;
213(6):779-794.
PMID: 39109924
Approaches to reverse or limit regulatory T cell (Treg) insufficiency are of great interest for development of immunotherapeutic treatments for autoimmune patients, including type 1 diabetes. Treg insufficiency is heavily...
13.
Mao X, Gu H, Kim D, Kimura Y, Wang N, Xu E, et al.
Nat Commun
. 2024 Jul;
15(1):6413.
PMID: 39080298
No abstract available.
14.
Mao X, Gu H, Kim D, Kimura Y, Wang N, Xu E, et al.
Nat Commun
. 2024 May;
15(1):4663.
PMID: 38821932
Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 that...
15.
Adam K, Lipatova Z, Abdul Ghafoor Raja M, Mishra A, Mariuzza R, Workman C, et al.
J Immunol
. 2024 May;
213(1):7-13.
PMID: 38775415
Lymphocyte activation gene 3 (LAG3) is an inhibitory receptor that plays a critical role in controlling T cell tolerance and autoimmunity and is a major immunotherapeutic target. LAG3 is expressed...
16.
Zdinak P, Trivedi N, Grebinoski S, Torrey J, Martinez E, Martinez S, et al.
Nat Methods
. 2024 Apr;
21(5):846-856.
PMID: 38658646
CD4 T cells recognize peptide antigens presented on class II major histocompatibility complex (MHC-II) molecules to carry out their function. The remarkable diversity of T cell receptor sequences and lack...
17.
Rao A, Zhang X, Cillo A, Sussman J, Sandlesh P, Tarbay A, et al.
bioRxiv
. 2024 Apr;
PMID: 38645178
Diffuse gliomas are epigenetically dysregulated, immunologically cold, and fatal tumors characterized by mutations in isocitrate dehydrogenase (IDH). Although IDH mutations yield a uniquely immunosuppressive tumor microenvironment, the regulatory mechanisms that...
18.
Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, et al.
Adv Sci (Weinh)
. 2024 Feb;
11(16):e2303775.
PMID: 38327094
The spread of prion-like protein aggregates is a common driver of pathogenesis in various neurodegenerative diseases, including Alzheimer's disease (AD) and related Tauopathies. Tau pathologies exhibit a clear progressive spreading...
19.
Baessler A, Vignali D
Annu Rev Immunol
. 2024 Jan;
42(1):179-206.
PMID: 38166256
T cell responses must be balanced to ensure adequate protection against malignant transformation and an array of pathogens while also limiting damage to healthy cells and preventing autoimmunity. T cell...
20.
Shan F, Cillo A, Cardello C, Yuan D, Kunning S, Cui J, et al.
Sci Immunol
. 2023 Sep;
8(87):eadf6717.
PMID: 37713508
Human regulatory T cells (T) are crucial regulators of tissue repair, autoimmune diseases, and cancer. However, it is challenging to inhibit the suppressive function of T for cancer therapy without...