Danielle P A Mascarenhas
Overview
Explore the profile of Danielle P A Mascarenhas including associated specialties, affiliations and a list of published articles.
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9
Citations
201
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Recent Articles
1.
Schmidt S, Mondino S, Gomez-Valero L, Escoll P, Mascarenhas D, Goncalves A, et al.
PLoS Pathog
. 2024 Sep;
20(9):e1012534.
PMID: 39259722
Legionella longbeachae and Legionella pneumophila are the most common causative agents of Legionnaires' disease. While the clinical manifestations caused by both species are similar, species-specific differences exist in environmental niches,...
2.
Loterio R, Thomas D, Andrade W, Lee Y, Santos L, Mascarenhas D, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(36):e2308752120.
PMID: 37639588
The causative agent of human Q fever, is highly adapted to infect alveolar macrophages by inhibiting a range of host responses to infection. Despite the clinical and biological importance of...
3.
Rodrigues T, Caetano C, de Sa K, Almeida L, Becerra A, Goncalves A, et al.
J Infect Dis
. 2023 Feb;
227(12):1364-1375.
PMID: 36763010
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers activation of the NLRP3 inflammasome, which promotes inflammation and aggravates severe COVID-19. Here, we report that SARS-CoV-2 induces upregulation and activation...
4.
Goncalves A, Margolis S, Quirino G, Mascarenhas D, Rauch I, Nichols R, et al.
PLoS Pathog
. 2019 Jun;
15(6):e1007886.
PMID: 31251782
Inflammasomes are cytosolic multi-protein complexes that detect infection or cellular damage and activate the Caspase-1 (CASP1) protease. The NAIP5/NLRC4 inflammasome detects bacterial flagellin and is essential for resistance to the...
5.
Mascarenhas D, Zamboni D
Methods Mol Biol
. 2019 Jan;
1921:305-319.
PMID: 30694501
Legionella pneumophila is a gram-negative bacterium that infects many species of unicellular protozoa in freshwater environments. The human infection is accidental, and the bacteria may not have evolved strategies to...
6.
Mascarenhas D, Cerqueira D, Pereira M, Castanheira F, Fernandes T, Manin G, et al.
PLoS Pathog
. 2017 Aug;
13(8):e1006502.
PMID: 28771586
Legionella pneumophila is a Gram-negative, flagellated bacterium that survives in phagocytes and causes Legionnaires' disease. Upon infection of mammalian macrophages, cytosolic flagellin triggers the activation of Naip/NLRC4 inflammasome, which culminates...
7.
Cunha L, Silva A, Ribeiro J, Mascarenhas D, Quirino G, Santos L, et al.
Cell Rep
. 2017 Jul;
20(4):794-805.
PMID: 28746866
Inflammasomes are multimeric protein complexes that initiate inflammatory cascades. Their activation is a hallmark of many infectious or inflammatory diseases. Their composition and activity are specified by proinflammatory stimuli. For...
8.
Mascarenhas D, Zamboni D
J Leukoc Biol
. 2016 Dec;
101(4):841-849.
PMID: 27999148
Inflammasomes are multimeric protein complexes that assemble in the cytosol of many types of cells, including innate immune cells. The inflammasomes can be activated in response to infection or in...
9.
Mascarenhas D, Pereira M, Manin G, Hori J, Zamboni D
J Infect Dis
. 2014 Aug;
211(2):322-30.
PMID: 25104770
Legionella pneumophila, the etiological agent of Legionnaires' disease, triggers activation of multiple innate immune pathways that lead to the restriction of bacterial replication in vivo. Despite the critical role for...