Danielle L Fink
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Explore the profile of Danielle L Fink including associated specialties, affiliations and a list of published articles.
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14
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734
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Recent Articles
1.
Priel D, Lau K, Fink D, Fink D, Kuhns D
J Immunol Methods
. 2025 Jan;
537:113820.
PMID: 39884497
Chronic granulomatous disease (CGD) is a rare immunodeficiency characterized by recurrent bacterial and fungal infections that are attributed to reduced production of reactive oxygen species (ROS) by a multi-component enzyme...
2.
Ham H, Jing H, Lamborn I, Kober M, Koval A, Berchiche Y, et al.
Science
. 2024 Sep;
385(6715):eadd8947.
PMID: 39298586
Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in , which encodes G, a key component in heterotrimeric G...
3.
Kanth S, Huapaya J, Gairhe S, Wang H, Tian X, Demirkale C, et al.
Cell Rep Med
. 2024 Jul;
5(7):101642.
PMID: 38981485
In order to assess homeostatic mechanisms in the lung after COVID-19, changes in the protein signature of bronchoalveolar lavage from 45 patients with mild to moderate disease at three phases...
4.
Zendt M, Bustos Carrillo F, Kelly S, Saturday T, Degrange M, Ginigeme A, et al.
Sci Adv
. 2023 Oct;
9(41):eadh3150.
PMID: 37824621
Research on coronavirus disease 2019 vaccination in immune-deficient/disordered people (IDP) has focused on cancer and organ transplantation populations. In a prospective cohort of 195 IDP and 35 healthy volunteers (HV),...
5.
Nunes-Santos C, Kuehn H, Boast B, Hwang S, Kuhns D, Stoddard J, et al.
Nat Commun
. 2023 Jun;
14(1):3708.
PMID: 37349293
We describe the first cases of germline biallelic null mutations in ARPC5, part of the Arp2/3 actin nucleator complex, in two unrelated patients presenting with recurrent and severe infections, early-onset...
6.
de Jesus A, Chen G, Yang D, Brdicka T, Ruth N, Bennin D, et al.
Nat Commun
. 2023 Mar;
14(1):1502.
PMID: 36932076
Neutrophilic inflammation is a hallmark of many monogenic autoinflammatory diseases; pathomechanisms that regulate extravasation of damaging immune cells into surrounding tissues are poorly understood. Here we identified three unrelated boys...
7.
Carmona-Rivera C, Zhang Y, Dobbs K, Markowitz T, Dalgard C, Oler A, et al.
JCI Insight
. 2022 Jul;
7(16).
PMID: 35852866
Dysregulation in neutrophil extracellular trap (NET) formation and degradation may play a role in the pathogenesis and severity of COVID-19; however, its role in the pediatric manifestations of this disease,...
8.
Sacco K, Castagnoli R, Vakkilainen S, Liu C, Delmonte O, Oguz C, et al.
Nat Med
. 2022 Feb;
28(5):1050-1062.
PMID: 35177862
Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might develop multisystem inflammatory syndrome in children (MIS-C),...
9.
Liu C, Martins A, Lau W, Rachmaninoff N, Chen J, Imberti L, et al.
Cell
. 2021 Mar;
184(7):1836-1857.e22.
PMID: 33713619
COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response variation to disease severity and outcome over time, we longitudinally assessed circulating proteins as well as 188 surface protein markers, transcriptome,...
10.
Abers M, Delmonte O, Ricotta E, Fintzi J, Fink D, de Jesus A, et al.
JCI Insight
. 2020 Nov;
6(1).
PMID: 33232303
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict...