Alexandra F Freeman
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Explore the profile of Alexandra F Freeman including associated specialties, affiliations and a list of published articles.
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232
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8731
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Recent Articles
1.
Czech M, Cuellar-Rodriguez J, Kwon-Chung K, Stock F, Aneke C, Olivier K, et al.
J Clin Microbiol
. 2025 Mar;
:e0155024.
PMID: 40052805
Reduced susceptibility to antifungals is common among members of genera and , with optimal treatments still not fully defined. antifungal susceptibility results and clinical data do not comprehensively account for...
2.
Chaturvedi M, Epling B, Pei L, Sullivan B, Kuehn H, Hammoud D, et al.
Transpl Infect Dis
. 2025 Feb;
:e70000.
PMID: 39964133
Immune reconstitution inflammatory syndrome (IRIS) is a well-recognized complication in people with HIV (PWH) starting antiretroviral therapy (ART), but data on IRIS in hematopoietic cell transplantation (HCT) recipients are limited....
3.
Bosticardo M, Dobbs K, Delmonte O, Martins A, Pala F, Kawai T, et al.
Sci Immunol
. 2025 Jan;
10(103):eadq1697.
PMID: 39792639
Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to a large group of -mutated patients, we aimed at characterizing the...
4.
Duran J, Sayed S, Dalalo M, Mauracher A, Knight M, Conrey P, et al.
bioRxiv
. 2024 Dec;
PMID: 39713308
Signal transduction downstream of activating stimuli controls CD8+ T cell biology, however these external inputs can become uncoupled from transcriptional regulation in Primary Immune Regulatory Disorders (PIRDs). Gain-of-function (GOF) variants...
5.
Wang C, Freeman A
Pathogens
. 2024 Nov;
13(11).
PMID: 39599507
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is highly conserved and essential for numerous biological functions triggered by extracellular signals, including cell proliferation, metabolism, immune response,...
6.
Olbrich P, Freeman A
Curr Opin Allergy Clin Immunol
. 2024 Oct;
24(6):440-447.
PMID: 39475850
Purpose Of Review: The identification of STAT1 gain-of-function (GOF) in 2011 and STAT3 GOF in 2014 has advanced our understanding of the host immunity along the JAK/STAT pathway and allowed...
7.
Samra S, Bergerson J, Freeman A, Turvey S
J Allergy Clin Immunol
. 2024 Oct;
155(2):357-367.
PMID: 39369964
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling cascade is an evolutionarily conserved signal transduction pathway that regulates many vital cellular processes, including immune function and hematopoiesis. Human...
8.
Ham H, Jing H, Lamborn I, Kober M, Koval A, Berchiche Y, et al.
Science
. 2024 Sep;
385(6715):eadd8947.
PMID: 39298586
Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in , which encodes G, a key component in heterotrimeric G...
9.
Freeman A, Gonzalez C, Yates B, Cole K, Little L, Flannelly E, et al.
J Allergy Clin Immunol
. 2024 Sep;
155(1):176-187.
PMID: 39233015
Background: DOCK8 deficiency is a primary immunodeficiency in which allogeneic hematopoietic cell transplantation (HCT) represents the only known cure. We tested the ability of a busulfan-based regimen to achieve reliable...
10.
Sun L, Walls S, Dang H, Quinney N, Sears P, Sadritabrizi T, et al.
bioRxiv
. 2024 Aug;
PMID: 39211176
Rationale: Hyper IgE syndrome (STAT3-HIES), also known as Job's syndrome, is a rare immunodeficiency disease typically caused by dominant-negative STAT3 mutations. STAT3-HIES syndrome is characterized by chronic pulmonary infection and...