Danielle Kerkhofs
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Explore the profile of Danielle Kerkhofs including associated specialties, affiliations and a list of published articles.
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12
Citations
187
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Recent Articles
1.
Voorter P, Stringer M, van Dinther M, Kerkhofs D, Dewenter A, Blair G, et al.
Stroke
. 2024 Dec;
56(1):128-137.
PMID: 39648904
Background: White matter hyperintensities (WMHs) are established structural imaging markers of cerebral small vessel disease. The pathophysiologic condition of brain tissue varies over the core, the vicinity, and the subtypes...
2.
Stringer M, Blair G, Kopczak A, Kerkhofs D, Thrippleton M, Chappell F, et al.
Ann Neurol
. 2024 Nov;
97(3):483-498.
PMID: 39552538
Objective: Cerebral small vessel diseases (SVDs) are associated with cerebrovascular dysfunction, such as increased blood-brain barrier leakage (permeability surface area product), vascular pulsatility, and decreased cerebrovascular reactivity (CVR). No studies...
3.
Kopczak A, Stringer M, van den Brink H, Kerkhofs D, Blair G, van Dinther M, et al.
Lancet Neurol
. 2023 Oct;
22(11):991-1004.
PMID: 37863608
Background: Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease....
4.
Rudilosso S, Stringer M, Thrippleton M, Chappell F, Blair G, Garcia D, et al.
J Cereb Blood Flow Metab
. 2023 May;
43(9):1490-1502.
PMID: 37132279
Blood-brain barrier (BBB) is known to be impaired in cerebral small vessel disease (SVD), and is measurable by dynamic-contrast enhancement (DCE)-MRI. In a cohort of 69 patients (42 sporadic, 27...
5.
Kerkhofs D, Helgers R, Hermes D, Steinbusch H, van Essen H, Leenders P, et al.
J Hypertens
. 2023 Apr;
41(7):1159-1167.
PMID: 37071429
Background: SBP and blood pressure variability are independent risk factors for cerebral small vessel disease, a leading cause for stroke and dementia. Calcium-channel blockers are known to reduce blood pressure...
6.
Kopczak A, Stringer M, van den Brink H, Kerkhofs D, Blair G, van Dinther M, et al.
Eur Stroke J
. 2023 Apr;
8(1):387-397.
PMID: 37021189
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (SVDs). Yet, it is unknown whether antihypertensive drug classes differentially affect microvascular function in SVDs. Aims: To...
7.
Blair G, Stringer M, Thrippleton M, Chappell F, Shuler K, Hamilton I, et al.
Cereb Circ Cogn Behav
. 2022 Nov;
2:100020.
PMID: 36324725
Background: Sporadic cerebral small vessel disease (SVD) and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) share clinical and neuroimaging features and possibly vascular dysfunction(s). However few studies...
8.
Rudilosso S, Chui E, Stringer M, Thrippleton M, Chappell F, Blair G, et al.
Neurology
. 2022 May;
99(5):e440-e452.
PMID: 35606147
Background And Objectives: Magnetic resonance susceptibility-weighted imaging (SWI) can identify small brain blood vessels that contain deoxygenated blood due to its induced magnetic field disturbance. We observed focal clusters of...
9.
Kerkhofs D, Wong S, Zhang E, Uiterwijk R, Hoff E, Jansen J, et al.
Geroscience
. 2021 Jun;
43(4):1643-1652.
PMID: 34160780
Blood-brain barrier (BBB) dysfunction is one of the pathophysiological mechanisms in cerebral small vessel disease (SVD). Previously, it was shown that BBB leakage volume is larger in patients with SVD...
10.
Kerkhofs D, Wong S, Zhang E, Staals J, Jansen J, van Oostenbrugge R, et al.
Neurology
. 2021 Mar;
96(17):e2192-e2200.
PMID: 33762423
Objective: To investigate the 2-year change in parenchymal diffusivity, a quantitative marker of microstructural tissue condition, and the relationship with baseline blood-brain barrier (BBB) permeability, in tissue at risk, i.e.,...