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Anna Kopczak

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Articles 47
Citations 563
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Recent Articles
1.
Voorter P, Stringer M, van Dinther M, Kerkhofs D, Dewenter A, Blair G, et al.
Stroke . 2024 Dec; 56(1):128-137. PMID: 39648904
Background: White matter hyperintensities (WMHs) are established structural imaging markers of cerebral small vessel disease. The pathophysiologic condition of brain tissue varies over the core, the vicinity, and the subtypes...
2.
Gravesteijn G, Rutten J, Cerfontaine M, Hack R, Liao Y, Jolly A, et al.
JAMA Neurol . 2024 Nov; 82(1):49-60. PMID: 39610302
Importance: Typical cysteine-altering NOTCH3 (NOTCH3cys) variants are highly prevalent (approximately 1 in 300 individuals) and are associated with a broad spectrum of small vessel disease (SVD), ranging from early-onset stroke...
3.
Stringer M, Blair G, Kopczak A, Kerkhofs D, Thrippleton M, Chappell F, et al.
Ann Neurol . 2024 Nov; 97(3):483-498. PMID: 39552538
Objective: Cerebral small vessel diseases (SVDs) are associated with cerebrovascular dysfunction, such as increased blood-brain barrier leakage (permeability surface area product), vascular pulsatility, and decreased cerebrovascular reactivity (CVR). No studies...
4.
Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, et al.
Nature . 2024 Aug; 633(8029):433-441. PMID: 39112714
The risk of early recurrent events after stroke remains high despite currently established secondary prevention strategies. Risk is particularly high in patients with atherosclerosis, with more than 10% of patients...
5.
Hoffmann V, Schonecker S, Amin M, Reidler P, Brauer A, Kopczak A, et al.
J Neurol . 2024 Jul; 271(9):6238-6246. PMID: 39085620
Background: Juvenile strokes (< 55 years) account for about 15% of all ischemic strokes. Structured data on clinical outcome in those patients are sparse. Here, we aimed to fill this...
6.
Saba L, Cau R, Kopczak A, Schindler A, Saam T
JACC Cardiovasc Imaging . 2024 Feb; 17(2):227. PMID: 38325961
No abstract available.
7.
Kopczak A, Stringer M, van den Brink H, Kerkhofs D, Blair G, van Dinther M, et al.
Lancet Neurol . 2023 Oct; 22(11):991-1004. PMID: 37863608
Background: Hypertension is the leading risk factor for cerebral small vessel disease. We aimed to determine whether antihypertensive drug classes differentially affect microvascular function in people with small vessel disease....
8.
Saba L, Cau R, Murgia A, Nicolaides A, Wintermark M, Castillo M, et al.
JACC Cardiovasc Imaging . 2023 Oct; 17(1):62-75. PMID: 37823860
Background: Carotid artery atherosclerosis is highly prevalent in the general population and is a well-established risk factor for acute ischemic stroke. Although the morphological characteristics of vulnerable plaques are well...
9.
Kolabas Z, Kuemmerle L, Perneczky R, Forstera B, Ulukaya S, Ali M, et al.
Cell . 2023 Aug; 186(17):3706-3725.e29. PMID: 37562402
The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear....
10.
Strecker C, Kopczak A, Saam T, Sepp D, Hennemuth A, Mayerhofer E, et al.
Front Cardiovasc Med . 2023 Jun; 10:1177998. PMID: 37378412
Introduction: Complicated carotid artery plaques (cCAPs) are associated with an increased risk of rupture and subsequent stroke. The geometry of the carotid bifurcation determines the distribution of local hemodynamics and...