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Danielle E Bear

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Articles 45
Citations 712
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Recent Articles
1.
Bear D, Lambell K, Stoppe C
Crit Care Clin . 2025 Feb; 41(2):247-262. PMID: 40021278
Nutrition therapy is a complex intervention with several underlying considerations that may influence effectiveness. Considerations include the mechanism of action of the intervention and the patient phenotype, including sex, ethnicity,...
2.
Rabheru R, Langan A, Merriweather J, Connolly B, Whelan K, Bear D
Am J Clin Nutr . 2025 Jan; 121(3):703-723. PMID: 39746396
Background: Surviving critical illness leads to prolonged physical and functional recovery with both nutritional and physical rehabilitation interventions for prevention and treatment being investigated. Nutritional status and adequacy may influence...
3.
Bachmann K, Jenkins B, Asrani V, Bear D, Bolondi G, Boraso S, et al.
Crit Care . 2024 Dec; 28(1):420. PMID: 39695807
Purpose: Gastrointestinal (GI) dysfunction is common in critically ill patients and associated with poor outcomes. There is a lack of standardised methods for daily monitoring of GI function. COSMOGI aimed...
4.
de Man A, Stoppe C, Stoppe C, Koekkoek K, Koekkoek W, Briassoulis G, et al.
JPEN J Parenter Enteral Nutr . 2024 Nov; 49(1):33-58. PMID: 39555865
Micronutrient (MN) status alterations (both depletion and deficiency) are associated with several complications and worse outcomes in critically ill patients. On the other side of the spectrum, improving MN status...
5.
Haines R, Granholm A, Puthucheary Z, Day A, Bear D, Prowle J, et al.
Br J Anaesth . 2024 Oct; 133(6):1192-1200. PMID: 39455305
Background: The EFFORT Protein trial assessed the effect of high vs usual dosing of protein in adult ICU patients with organ failure. This study provides a probabilistic interpretation and evaluates...
6.
Bear D, Summers M, Chapple L
Curr Opin Clin Nutr Metab Care . 2024 Aug; 27(6):479-485. PMID: 39150402
Purpose Of Review: Critical care nutrition guidelines recommend provision of higher protein doses than recommended in health. These recommendations have been predominately based on lower quality evidence and physiological rationale...
7.
Haines R, Prowle J, Day A, Bear D, Heyland D, Puthucheary Z
Crit Care . 2024 Jan; 28(1):24. PMID: 38229072
Background: Delivering higher doses of protein to mechanically ventilated critically ill patients did not improve patient outcomes and may have caused harm. Longitudinal urea measurements could provide additional information about...
8.
McNelly A, Langan A, Bear D, Page A, Martin T, Seidu F, et al.
Nat Commun . 2023 Dec; 14(1):8345. PMID: 38102152
Bioenergetic failure caused by impaired utilisation of glucose and fatty acids contributes to organ dysfunction across multiple tissues in critical illness. Ketone bodies may form an alternative substrate source, but...
9.
Tweel L, Compher C, Bear D, Gutierrez-Castrellon P, Leaver S, MacEachern K, et al.
Crit Care Med . 2023 Nov; 52(4):586-595. PMID: 37930244
Objectives: Across guidelines, protein dosing for critically ill patients with obesity varies considerably. The objective of this analysis was to evaluate whether this population would benefit from higher doses of...
10.
Thibault R, Bear D, Fischer A, Montejo-Gonzalez J, Hiesmayr M, Tamasi P, et al.
Clin Nutr ESPEN . 2023 Sep; 57:318-330. PMID: 37739675
Nutritional assessment and provision of nutritional therapy are a core part of intensive care unit (ICU) patient treatment. The ESPEN guideline on clinical nutrition in the ICU was published in...