Daniele Carvalho Nascimento
Overview
Explore the profile of Daniele Carvalho Nascimento including associated specialties, affiliations and a list of published articles.
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12
Citations
961
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Recent Articles
1.
Toller-Kawahisa J, Viacava P, Palsson-McDermott E, Nascimento D, Cervantes-Silva M, OCarroll S, et al.
Cell Rep
. 2025 Jan;
44(1):115172.
PMID: 39772395
Macrophages play a crucial role in immune responses and undergo metabolic reprogramming to fulfill their functions. The tetramerization of the glycolytic enzyme pyruvate kinase M2 (PKM2) induces the production of...
2.
Haruo Fernandes de Lima M, Machado C, Nascimento D, Silva C, Toller-Kawahisa J, Rodrigues T, et al.
Sci Rep
. 2023 Aug;
13(1):13599.
PMID: 37604833
The TIGITFOXP3Treg subset (TIGITTregs) exerts robust suppressive activity on cellular immunity and predisposes septic individuals to opportunistic infection. We hypothesized that TIGITTregs could play an important role in intensifying the...
3.
Toller-Kawahisa J, Hiroki C, Silva C, Nascimento D, Publio G, Martins T, et al.
Nat Commun
. 2023 Jul;
14(1):4280.
PMID: 37460614
Neutrophils rely predominantly on glycolytic metabolism for their biological functions, including reactive oxygen species (ROS) production. Although pyruvate kinase M2 (PKM2) is a glycolytic enzyme known to be involved in...
4.
Silva C, Wanderley C, Veras F, Goncalves A, Lima M, Toller-Kawahisa J, et al.
Crit Care
. 2022 Jul;
26(1):206.
PMID: 35799268
Background: The release of neutrophil extracellular traps (NETs) is associated with inflammation, coagulopathy, and organ damage found in severe cases of COVID-19. However, the molecular mechanisms underlying the release of...
5.
Damasceno L, Cebinelli G, Fernandes M, Nascimento D, Publio G, Vinolo M, et al.
Cell Rep
. 2022 May;
39(8):110838.
PMID: 35613599
External and intrinsic factors regulate the transcriptional profile of T helper 17 (T17) cells, thereby affecting their pathogenic potential and revealing their context-dependent plasticity. The stimulator of interferon genes (STING),...
6.
Nascimento D, Viacava P, Ferreira R, Damaceno M, Pineros A, Melo P, et al.
Immunity
. 2021 Sep;
54(9):2024-2041.e8.
PMID: 34473957
Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop persistent immunosuppression with increased risk of recurrent infections. We utilized...
7.
Veras F, Cornejo Pontelli M, Silva C, Toller-Kawahisa J, de Lima M, Nascimento D, et al.
J Exp Med
. 2020 Sep;
217(12).
PMID: 32926098
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil extracellular traps (NETs) have been described as important...
8.
Sonego F, Vargas E Silva Castanheira F, Ferreira R, Kanashiro A, Leite C, Nascimento D, et al.
Front Immunol
. 2016 May;
7:155.
PMID: 27199981
Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide. Neutrophils are classically considered to be essential players in the host...
9.
Czaikoski P, Mota J, Nascimento D, Sonego F, Vargas E Silva Castanheira F, Melo P, et al.
PLoS One
. 2016 Feb;
11(2):e0148142.
PMID: 26849138
Organ dysfunction is a major concern in sepsis pathophysiology and contributes to its high mortality rate. Neutrophil extracellular traps (NETs) have been implicated in endothelial damage and take part in...
10.
Niedbala W, Besnard A, Nascimento D, Donate P, Sonego F, Yip E, et al.
Nat Commun
. 2014 Aug;
5:4575.
PMID: 25099390
Th9 cells protect hosts against helminthic infection but also mediate allergic disease. Here we show that nitric oxide (NO) promotes Th9 cell polarization of murine and human CD4(+) T cells....