Daniel Y L Mao
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Explore the profile of Daniel Y L Mao including associated specialties, affiliations and a list of published articles.
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16
Citations
806
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Recent Articles
1.
Bruce H, Singer A, Filippova E, Blazer L, Adams J, Enderle L, et al.
Protein Sci
. 2023 Nov;
33(1):e4824.
PMID: 37945533
The atomic-resolution structural information that X-ray crystallography can provide on the binding interface between a Fab and its cognate antigen is highly valuable for understanding the mechanism of interaction. However,...
2.
Beenstock J, Ona S, Porat J, Orlicky S, Wan L, Ceccarelli D, et al.
Nat Commun
. 2020 Dec;
11(1):6233.
PMID: 33277478
The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the fitness of all organisms...
3.
Xiong S, Lorenzen K, Couzens A, Templeton C, Rajendran D, Mao D, et al.
Structure
. 2018 Jul;
26(8):1101-1115.e6.
PMID: 29983373
The human NDR family kinases control diverse aspects of cell growth, and are regulated through phosphorylation and association with scaffolds such as MOB1. Here, we report the crystal structure of...
4.
Huang H, Zeqiraj E, Dong B, Jha B, Duffy N, Orlicky S, et al.
Mol Cell
. 2014 Jan;
53(2):221-34.
PMID: 24462203
RNase L is an ankyrin repeat domain-containing dual endoribonuclease-pseudokinase that is activated by unusual 2,'5'-oligoadenylate (2-5A) second messengers and which impedes viral infections in higher vertebrates. Despite its importance in...
5.
Lavoie H, Thevakumaran N, Gavory G, Li J, Padeganeh A, Guiral S, et al.
Nat Chem Biol
. 2013 May;
9(7):428-36.
PMID: 23685672
RAF kinases have a prominent role in cancer. Their mode of activation is complex but critically requires dimerization of their kinase domains. Unexpectedly, several ATP-competitive RAF inhibitors were recently found...
6.
Wan L, Mao D, Neculai D, Strecker J, Chiovitti D, Kurinov I, et al.
Nucleic Acids Res
. 2013 Apr;
41(12):6332-46.
PMID: 23620299
The universally conserved Kae1/Qri7/YgjD and Sua5/YrdC protein families have been implicated in growth, telomere homeostasis, transcription and the N6-threonylcarbamoylation (t(6)A) of tRNA, an essential modification required for translational fidelity by...
7.
Juang Y, Landry M, Sanches M, Vittal V, Leung C, Ceccarelli D, et al.
Mol Cell
. 2012 Feb;
45(3):384-97.
PMID: 22325355
Ubiquitylation entails the concerted action of E1, E2, and E3 enzymes. We recently reported that OTUB1, a deubiquitylase, inhibits the DNA damage response independently of its isopeptidase activity. OTUB1 does...
8.
Mao D, Neculai D, Downey M, Orlicky S, Haffani Y, Ceccarelli D, et al.
Mol Cell
. 2008 Oct;
32(2):259-75.
PMID: 18951093
Kae1 is a universally conserved ATPase and part of the essential gene set in bacteria. In archaea and eukaryotes, Kae1 is embedded within the protein kinase-containing KEOPS complex. Mutation of...
9.
Mao D, Ceccarelli D, Sicheri F
Mol Cell
. 2008 Mar;
29(5):535-7.
PMID: 18342599
In this issue of Molecular Cell, Ngo et al. (2008) describe the crystal structure of the SRPK1 protein kinase in complex with its substrate, the spliceosome factor ASF/SF2, providing an...
10.
Kim S, Shago M, Kaustov L, Boutros P, Clendening J, Sheng Y, et al.
Cancer Res
. 2007 Oct;
67(20):9616-22.
PMID: 17942889
Using an expression cloning approach, we identify CUL7, a member of the cullin family, as a functional inhibitor of Myc-induced apoptosis. Deregulated expression of the Myc oncogene drives cellular proliferation...