"Unraveling the Tail" of How SRPK1 Phosphorylates ASF/SF2

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2008 Mar 18

PMID 18342599

Citations 4

Authors

Daniel Y L Mao

Derek F Ceccarelli

Frank Sicheri

Affiliations

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Abstract

In this issue of Molecular Cell, Ngo et al. (2008) describe the crystal structure of the SRPK1 protein kinase in complex with its substrate, the spliceosome factor ASF/SF2, providing an unprecedented view of multiple targeting mechanisms in action on a single substrate.

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