Daniel W Kneller
Overview
Explore the profile of Daniel W Kneller including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
33
Citations
732
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Aniana A, Nashed N, Ghirlando R, Coates L, Kneller D, Kovalevsky A, et al.
Commun Biol
. 2023 Nov;
6(1):1159.
PMID: 37957287
A critical step for SARS-CoV-2 assembly and maturation involves the autoactivation of the main protease (MPro) from precursor polyproteins. Upon expression, a model precursor of MPro mediates its own release...
2.
A novel family of sugar-specific phosphodiesterases that remove zwitterionic modifications of GlcNAc
Fossa S, Anton B, Kneller D, Petralia L, Ganatra M, Boisvert M, et al.
J Biol Chem
. 2023 Nov;
299(12):105437.
PMID: 37944617
The zwitterions phosphorylcholine (PC) and phosphoethanolamine (PE) are often found esterified to certain sugars in polysaccharides and glycoconjugates in a wide range of biological species. One such modification involves PC...
3.
Chan S, Mole C, Nye D, Mitchell L, Dai N, Buss J, et al.
RNA
. 2023 Aug;
29(11):1803-1817.
PMID: 37625853
The mammalian mRNA 5' cap structures play important roles in cellular processes such as nuclear export, efficient translation, and evading cellular innate immune surveillance and regulating 5'-mediated mRNA turnover. Hence,...
4.
Joshi R, Schultz K, Wilson J, Kruel A, Varikoti R, Kombala C, et al.
J Chem Inf Model
. 2023 Feb;
63(5):1438-1453.
PMID: 36808989
Direct-acting antivirals for the treatment of the COVID-19 pandemic caused by the SARS-CoV-2 virus are needed to complement vaccination efforts. Given the ongoing emergence of new variants, automated experimentation, and...
5.
Kovalevsky A, Coates L, Kneller D, Ghirlando R, Aniana A, Nashed N, et al.
J Mol Biol
. 2022 Nov;
434(24):167876.
PMID: 36334779
We recently demonstrated that inhibitor binding reorganizes the oxyanion loop of a monomeric catalytic domain of SARS CoV-2 main protease (MPro) from an unwound (E) to a wound (active, E*)...
6.
Nashed N, Kneller D, Coates L, Ghirlando R, Aniana A, Kovalevsky A, et al.
Commun Biol
. 2022 Sep;
5(1):976.
PMID: 36114420
The monomeric catalytic domain (residues 1-199) of SARS-CoV-2 main protease (MPro) fused to 25 amino acids of its flanking nsp4 region mediates its autoprocessing at the nsp4-MPro junction. We report...
7.
Wong-Sam A, Wang Y, Kneller D, Kovalevsky A, Ghosh A, Harrison R, et al.
J Mol Graph Model
. 2022 Sep;
117:108315.
PMID: 36108568
Antiretroviral drug resistance is a therapeutic obstacle for people with HIV. HIV protease inhibitors darunavir and lopinavir are recommended for resistant infections. We characterized a protease mutant (PR10x) derived from...
8.
Hameedi M, Prates E, Garvin M, Mathews I, Amos B, Demerdash O, et al.
Nat Commun
. 2022 Sep;
13(1):5285.
PMID: 36075915
In addition to its essential role in viral polyprotein processing, the SARS-CoV-2 3C-like protease (3CLpro) can cleave human immune signaling proteins, like NF-κB Essential Modulator (NEMO) and deregulate the host...
9.
Correy G, Kneller D, Phillips G, Pant S, Russi S, Cohen A, et al.
Sci Adv
. 2022 May;
8(21):eabo5083.
PMID: 35622909
The nonstructural protein 3 (NSP3) macrodomain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Mac1) removes adenosine diphosphate (ADP) ribosylation posttranslational modifications, playing a key role in the immune evasion...
10.
Kneller D, Li H, Phillips G, Weiss K, Zhang Q, Arnould M, et al.
Nat Commun
. 2022 Apr;
13(1):2268.
PMID: 35477935
Emerging SARS-CoV-2 variants continue to threaten the effectiveness of COVID-19 vaccines, and small-molecule antivirals can provide an important therapeutic treatment option. The viral main protease (M) is critical for virus...