Daniel Thedens
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Explore the profile of Daniel Thedens including associated specialties, affiliations and a list of published articles.
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18
Citations
220
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Recent Articles
1.
Sadjadi R, Picher-Martel V, Morrow J, Thedens D, DiCamillo P, McCray B, et al.
Neurology
. 2024 Aug;
103(5):e209763.
PMID: 39133880
Background And Objectives: Charcot-Marie-Tooth disease type 4J (CMT4J) is caused by autosomal recessive variants in the () gene. Recent preclinical work has demonstrated the feasibility of adeno-associated virus serotype 9-FIG4...
2.
Rodriguez S, Sharma S, Tiarks G, Peterson Z, Jackson K, Thedens D, et al.
Sci Rep
. 2024 Jun;
14(1):13507.
PMID: 38867062
Traumatic Brain Injury (TBI) induces neuroinflammatory response that can initiate epileptogenesis, which develops into epilepsy. Recently, we identified anti-convulsive effects of naltrexone, a mu-opioid receptor (MOR) antagonist, used to treat...
3.
Doherty C, Howard P, ODonnell L, Zuccarino R, Wastling S, Milev E, et al.
Ann Neurol
. 2024 Apr;
96(1):170-174.
PMID: 38613459
Quantitative muscle fat fraction (FF) responsiveness is lower in younger Charcot-Marie-Tooth disease type 1A (CMT1A) patients with lower baseline calf-level FF. We investigated the practicality, validity, and responsiveness of foot-level...
4.
Doherty C, Morrow J, Zuccarino R, Howard P, Wastling S, Pipis M, et al.
Ann Clin Transl Neurol
. 2024 Jan;
11(3):607-617.
PMID: 38173284
Objective: With potential therapies for many forms of Charcot-Marie-Tooth disease (CMT), responsive outcome measures are urgently needed for clinical trials. Quantitative lower limb MRI demonstrated progressive calf intramuscular fat accumulation...
5.
Lyden P, Diniz M, Bosetti F, Lamb J, Nagarkatti K, Rogatko A, et al.
Sci Transl Med
. 2023 Sep;
15(714):eadg8656.
PMID: 37729432
Human diseases may be modeled in animals to allow preclinical assessment of putative new clinical interventions. Recent, highly publicized failures of large clinical trials called into question the rigor, design,...
6.
Wang R, Peterson Z, Balasubramanian N, Khan K, Chimenti M, Thedens D, et al.
bioRxiv
. 2023 Aug;
PMID: 37609170
Schizophrenia is marked by poor social functioning that can have a severe impact on quality of life and independence, but the underlying neural circuity is not well understood. Here we...
7.
Lyden P, Bosetti F, Diniz M, Rogatko A, Koenig J, Lamb J, et al.
Stroke
. 2022 Mar;
53(5):1802-1812.
PMID: 35354299
Cerebral ischemia and reperfusion initiate cellular events in brain that lead to neurological disability. Investigating these cellular events provides ample targets for developing new treatments. Despite considerable work, no such...
8.
Dhanesha N, Patel R, Doddapattar P, Ghatge M, Flora G, Jain M, et al.
Blood
. 2021 Sep;
139(8):1234-1245.
PMID: 34529778
There is a critical need for cerebro-protective interventions to improve the suboptimal outcomes of patients with ischemic stroke who have been treated with reperfusion strategies. We found that nuclear pyruvate...
9.
Guo Z, Zhang H, Chen Z, van der Plas E, Gutmann L, Thedens D, et al.
Comput Med Imaging Graph
. 2020 Dec;
87:101835.
PMID: 33373972
Automated segmentation of individual calf muscle compartments from 3D magnetic resonance (MR) images is essential for developing quantitative biomarkers for muscular disease progression and its prediction. Achieving clinically acceptable results...
10.
Shusterman V, Nagpal P, Thedens D, Zhu X, Matasic D, Yoon J, et al.
Biomed Phys Eng Express
. 2020 Aug;
5(4).
PMID: 32733693
Objective: Integrating cardiac-tissue patches into the beating heart and evaluating the long-term effects of such integration on cardiac contractility are two challenges in an emerging field of regenerative medicine. This...