Daniel T Patton
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Explore the profile of Daniel T Patton including associated specialties, affiliations and a list of published articles.
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15
Citations
656
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Recent Articles
1.
Gardell J, Maurer M, Childs M, Pham M, Meengs B, Julien S, et al.
Front Immunol
. 2024 Nov;
15:1452537.
PMID: 39559361
Introduction: Regulatory CD8 T cells (CD8 Treg) are responsible for the selective killing of self-reactive and pathogenic CD4 T cells. In autoimmune disease, CD8 Treg may accumulate in the peripheral...
2.
Stark A, Davenport E, Patton D, Scudamore C, Vanhaesebroeck B, Veldhoen M, et al.
J Immunol
. 2020 May;
205(1):78-89.
PMID: 32414808
Class I PI3K enzymes are critical for the maintenance of effective immunity. In T cells, PI3Kα and PI3Kδ are activated by the TCR and costimulatory receptors, whereas PI3Kγ is activated...
3.
Plumb A, Sheikh A, Carlow D, Patton D, Ziltener H, Abraham N
Immunol Cell Biol
. 2017 Aug;
95(10):916-924.
PMID: 28811625
Interleukin-7 (IL-7) is essential for the development of T cells in humans and mice where deficiencies in IL-7 signaling result in severe immunodeficiency. T cells require IL-7 at multiple points...
4.
Patton D, Plumb A, Abraham N
J Immunol
. 2014 Aug;
193(7):3446-55.
PMID: 25143441
IL-7 is critical for murine T and B cell development and survival and plays a significant role in lymphoblastic leukemia in both humans and mice. We evaluated the role of...
5.
Patton D, Plumb A, Redpath S, Osborne L, Perona-Wright G, Abraham N
PLoS One
. 2014 Feb;
9(2):e88771.
PMID: 24551160
IL-7 is a critical cytokine for lymphocyte development. Recent work has highlighted critical roles for IL-7 signaling in mature T cell homeostasis and function, but its role in B cells...
6.
Plumb A, Patton D, Seo J, Loveday E, Jean F, Ziegler S, et al.
PLoS One
. 2012 Nov;
7(11):e50199.
PMID: 23189186
The immune response to viral infection is ideally rapid and specific, resulting in viral clearance and establishment of immune memory. Some viruses such as HIV can evade such responses leading...
7.
Soond D, Slack E, Garden O, Patton D, Okkenhaug K
Front Immunol
. 2012 Aug;
3:244.
PMID: 22912633
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is...
8.
Soond D, Garcon F, Patton D, Rolf J, Turner M, Scudamore C, et al.
J Immunol
. 2012 May;
188(12):5935-43.
PMID: 22611241
PTEN, one of the most commonly mutated or lost tumor suppressors in human cancers, antagonizes signaling by the PI3K pathway. Mice with thymocyte-specific deletion of Pten rapidly develop peripheral lymphomas...
9.
Patton D, Wilson M, Rowan W, Soond D, Okkenhaug K
PLoS One
. 2011 Mar;
6(3):e17359.
PMID: 21390257
The PI3K pathway has emerged as a key regulator of regulatory T cell (Treg) development and homeostasis and is required for full Treg-mediated suppression. To identify new genes involved in...
10.
Lawson C, Donald S, Anderson K, Patton D, Welch H
J Immunol
. 2010 Dec;
186(3):1467-76.
PMID: 21178006
G protein-coupled receptor (GPCR) activation elicits neutrophil responses such as chemotaxis and reactive oxygen species (ROS) formation, which depend on the small G protein Rac and are essential for host...