Daniel T Patton
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Explore the profile of Daniel T Patton including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
656
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Recent Articles
11.
Soond D, Bjorgo E, Moltu K, Dale V, Patton D, Torgersen K, et al.
Blood
. 2010 Jan;
115(11):2203-13.
PMID: 20081091
We have previously described critical and nonredundant roles for the phosphoinositide 3-kinase p110delta during the activation and differentiation of naive T cells, and p110delta inhibitors are currently being developed for...
12.
Garcon F, Patton D, Emery J, Hirsch E, Rottapel R, Sasaki T, et al.
Blood
. 2007 Nov;
111(3):1464-71.
PMID: 18006698
Activation of PI3K is among the earliest signaling events observed in T cells after conjugate formation with antigen-presenting cells (APCs). The relevant PI3K catalytic isoform and relative contribution of the...
13.
Patton D, Garden O, Pearce W, Clough L, Monk C, Leung E, et al.
J Immunol
. 2006 Nov;
177(10):6598-602.
PMID: 17082571
CD4+CD25+Foxp3+ regulatory T cells (Tregs) contribute to the maintenance of peripheral tolerance by inhibiting the expansion and function of conventional T cells. Treg development and homeostasis are regulated by the...
14.
Okkenhaug K, Patton D, Bilancio A, Garcon F, Rowan W, Vanhaesebroeck B
J Immunol
. 2006 Oct;
177(8):5122-8.
PMID: 17015696
The role of PI3K in T cell activation and costimulation has been controversial. We previously reported that a kinase-inactivating mutation (D910A) in the p110delta isoform of PI3K results in normal...
15.
Ramage J, Metheringham R, Conn A, Spendlove I, Moss R, Patton D, et al.
Int J Cancer
. 2004 Apr;
110(2):245-50.
PMID: 15069689
Tie-2 stabilises pericyte-endothelial interactions during angiogenesis and is highly expressed on endothelium during several diseases, including arthritis, age-related macular degeneration and cancer. A vaccine that targets endothelium overexpressing Tie-2 may...