Daniel S Perrien
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Explore the profile of Daniel S Perrien including associated specialties, affiliations and a list of published articles.
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53
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Recent Articles
1.
Dar H, Perrien D, Pal S, Stoica A, Uppuganti S, Nyman J, et al.
J Clin Invest
. 2023 Mar;
133(8).
PMID: 36881482
IL-17A (IL-17), a driver of the inflammatory phase of fracture repair, is produced locally by several cell lineages including γδ T cells and Th17 cells. However, the origin of these...
2.
Denys A, Norman A, Perrien D, Suva L, Simon L, McDaniel L, et al.
JBMR Plus
. 2023 Jan;
7(1):e10703.
PMID: 36699637
People living with HIV (PLWH) represent a vulnerable population to adverse musculoskeletal outcomes due to HIV infection, antiretroviral therapy (ART), and at-risk alcohol use. Developing measures to prevent skeletal degeneration...
3.
The microbiome restrains melanoma bone growth by promoting intestinal NK and Th1 cell homing to bone
Pal S, Perrien D, Yumoto T, Faccio R, Stoica A, Adams J, et al.
J Clin Invest
. 2022 May;
132(12).
PMID: 35503658
Bone metastases are frequent complications of malignant melanoma leading to reduced quality of life and significant morbidity. Regulation of immune cells by the gut microbiome influences cancer progression, but the...
4.
Yamaguchi H, Kitami M, Uchima Koecklin K, He L, Wang J, Lagor W, et al.
Dev Biol
. 2021 Dec;
482:91-100.
PMID: 34929174
Ciliogenic components, such as the family of intraflagellar transport (IFT) proteins, are recognized to play key roles in endochondral ossification, a critical process to form most bones. However, the unique...
5.
Lyu H, Elkins C, Pierce J, Serezani C, Perrien D
Biomedicines
. 2021 Jul;
9(6).
PMID: 34206078
Excess inflammation and canonical BMP receptor (BMPR) signaling are coinciding hallmarks of the early stages of injury-induced endochondral heterotopic ossification (EHO), especially in the rare genetic disease fibrodysplasia ossificans progressiva...
6.
Pierce J, Perrien D
Curr Osteoporos Rep
. 2021 Apr;
19(3):358-367.
PMID: 33851285
Purpose Of Review: Fibrodysplasia ossificans progressiva (FOP) is a debilitating rare disease known for episodic endochondral heterotopic ossification (HO) caused by gain-of-function mutations in ACVR1/ALK2. However, disease severity varies among...
7.
Thayer T, Lino Cardenas C, Martyn T, Nicholson C, Traeger L, Wunderer F, et al.
Sci Rep
. 2020 Jun;
10(1):9831.
PMID: 32561790
Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of...
8.
Lee D, Lee D, Uppuganti S, Perrien D, Pappas 3rd N, Reasoner K, et al.
J Wrist Surg
. 2020 Apr;
9(2):116-123.
PMID: 32257612
This article reviews the results of a surgical technique using three iterations of , autologous cancellous bone grafting ( ), and use of an intraosseous compression screw for the treatment...
9.
Pan H, Fleming N, Hong C, Mishina Y, Perrien D
J Musculoskelet Neuronal Interact
. 2020 Mar;
20(1):149-159.
PMID: 32131380
Objectives: Conditional () mice have previously been used as a model of heterotopic ossification (HO). However, HO formation in this model can be highly variable, and it is unclear which...
10.
Laroumanie F, Korneva A, Bersi M, Alexander M, Xiao L, Zhong X, et al.
JCI Insight
. 2018 Oct;
3(20).
PMID: 30333305
Aortic dissection (AD) is a life-threatening vascular disease with limited treatment strategies. Here, we show that loss of the GWAS-identified SH2B3 gene, encoding lymphocyte adaptor protein LNK, markedly increases susceptibility...