Daniel P Tonge
Overview
Explore the profile of Daniel P Tonge including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
100
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0
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Recent Articles
1.
Hoolachan J, McCallion E, Sutton E, Cetin O, Pacheco-Torres P, Dimitriadi M, et al.
Hum Mol Genet
. 2023 Nov;
33(5):400-425.
PMID: 37947217
Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by the reduction of survival of motor neuron (SMN) protein levels. Although three SMN-augmentation therapies are clinically approved that significantly...
2.
Hyland M, Mennan C, Davies R, Wilson E, Tonge D, Clayton A, et al.
Stem Cell Rev Rep
. 2023 Jul;
19(7):2391-2406.
PMID: 37474869
Autoimmune conditions, such as rheumatoid arthritis, are characterised by a loss of immune tolerance, whereby the immune cells attack self-antigens causing pain and inflammation. These conditions can be brought into...
3.
Kavousi N, Tonge D, Mourtada-Maarabouni M
Int J Biol Macromol
. 2023 Feb;
233:123467.
PMID: 36731689
The serine/threonine protein phosphatase 4 holoenzyme consists of a PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits. Previous studies have shown that PP4c acts as a tumour...
4.
Hammad D, Hider S, Liyanapathirana V, Tonge D
Front Cell Infect Microbiol
. 2020 Feb;
9:440.
PMID: 32039040
Rheumatoid Arthritis (RA) has been increasingly associated with perturbations to the microbial communities that reside in and on the body (the microbiome), in both human and animal studies. To date,...
5.
Bountali A, Tonge D, Mourtada-Maarabouni M
Int J Biol Macromol
. 2019 Mar;
130:878-891.
PMID: 30836187
Myocardial Infarction Associated Transcript (MIAT) is a subnuclear lncRNA that interferes with alternative splicing and is associated with increased risk of various heart conditions and nervous system tumours. The current...
6.
Amplicon-based metagenomic analysis of mixed fungal samples using proton release amplicon sequencing
Tonge D, Pashley C, Gant T
PLoS One
. 2014 Apr;
9(4):e93849.
PMID: 24728005
Next generation sequencing technology has revolutionised microbiology by allowing concurrent analysis of whole microbial communities. Here we developed and verified similar methods for the analysis of fungal communities using a...
7.
Tonge D, Bardsley R, Parr T, Maciewicz R, Jones S
Longev Healthspan
. 2014 Jan;
2(1):15.
PMID: 24472412
Background: Osteoarthritis (OA) is the most common joint disorder in the world and represents the leading cause of pain and disability in the elderly population. Advancing age remains the single...
8.
Tonge D, Tugwood J, Kelsall J, Gant T
BMC Genomics
. 2013 May;
14:338.
PMID: 23688202
Background: Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes involved in extracellular matrix (ECM) homeostasis. MMPs have been an attractive pharmacological target for a number of indications. However, development...
9.
Tonge D, Jones S, Bardsley R, Parr T
BMC Mol Biol
. 2010 Jul;
11:52.
PMID: 20587025
Background: Several chronic conditions leading to skeletal muscle dysfunction are known to be associated with changes in the expression of myosin heavy chain (MHC) isoforms at both the mRNA and...