Daniel Madsen
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Explore the profile of Daniel Madsen including associated specialties, affiliations and a list of published articles.
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6
Citations
49
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Recent Articles
1.
Petersen L, Christensen A, Andersen J, Folkesson C, Kristensen O, Andersen C, et al.
J Am Chem Soc
. 2021 Feb;
143(7):2751-2756.
PMID: 33577316
DNA-encoded small molecule libraries (DELs) have facilitated the discovery of novel modulators of many different therapeutic protein targets. We report the first successful screening of a multimillion membered DEL inside...
2.
Wang Y, Oliveira M, Madsen D, Thompson A, Meldal M, Diness F
Chemistry
. 2020 Aug;
26(68):15825-15829.
PMID: 32790088
A variant of the A coupling reaction was developed utilizing in situ generated N-carbamoyliminium ions. The tandem INCIC/A -coupling sequence provided a facile one-pot synthesis of dihydroquinazolinone derivatives. The scope...
3.
Madsen D, Azevedo C, Micco I, Petersen L, Hansen N
Prog Med Chem
. 2020 May;
59:181-249.
PMID: 32362328
DNA-encoded libraries (DELs) are collections of small molecules covalently attached to amplifiable DNA tags carrying unique information about the structure of each library member. A combinatorial approach is used to...
4.
Madsen D, Jorgensen F, Palmer D, Roux M, Olsen J, Bols M, et al.
ACS Comb Sci
. 2020 Feb;
22(3):156-164.
PMID: 32027120
On the basis of computational design, a focused one-bead one-compound library has been prepared on microparticle-encoded PEGA beads consisting of small tripeptides with a triazole-capped -terminal. The library was screened...
5.
Jorgensen F, Madsen D, Meldal M, Olsen J, Petersen M, Granhoj J, et al.
J Med Chem
. 2019 May;
62(10):5191-5216.
PMID: 31059249
A series of 35 analogues of Shld with modifications in the A-residue and the C-residues were prepared and investigated for binding to FKBP and GFP accumulation in transgenic plants. The...
6.
Ascic E, Ohm R, Petersen R, Hansen M, Hansen C, Madsen D, et al.
Chemistry
. 2014 Mar;
20(12):3297-300.
PMID: 24616060
A ruthenium hydride/Brønsted acid-catalyzed tandem sequence is reported for the synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]indoles (THPIs) and related oxacyclic scaffolds. The process was designed on the premise that readily available allylic ethers...