Daniel L Worthley
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Explore the profile of Daniel L Worthley including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Radford G, Vrbanac L, de Nys R, Worthley D, Wright J, Hasty J, et al.
Cancers (Basel)
. 2024 Sep;
16(17).
PMID: 39272829
The last decade has seen a rapid increase in studies utilising a genetically modified probiotic, Nissle 1917 (EcN), as a chassis for cancer treatment and detection. This approach relies on...
2.
Kobayashi H, Iida T, Ochiai Y, Malagola E, Zhi X, White R, et al.
Cancer Discov
. 2024 Aug;
15(1):202-226.
PMID: 39137067
Our work demonstrates that the bidirectional interplay between sympathetic nerves and NGF-expressing CAFs drives colorectal tumorigenesis. This study also offers novel mechanistic insights into catecholamine action in colorectal cancer. Inhibiting...
3.
Niikura R, Hayakawa Y, Nagata N, Miyoshi-Akiayama T, Miyabayashi K, Tsuboi M, et al.
Gastro Hep Adv
. 2024 Aug;
2(5):684-700.
PMID: 39129877
Background And Aims: Although is the most important bacterial carcinogen in gastric cancer (GC), GC can emerge even after eradication. Studies suggest that various constituents of the gastric microbiome may...
4.
Arai J, Hayakawa Y, Tateno H, Murakami K, Hayashi T, Hata M, et al.
Gastroenterology
. 2024 Apr;
167(3):505-521.e19.
PMID: 38583723
Background & Aims: Gastric cancer is often accompanied by a loss of mucin 6 (MUC6), but its pathogenic role in gastric carcinogenesis remains unclear. Methods: Muc6 knockout (Muc6) mice and...
5.
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia
Gurbatri C, Radford G, Vrbanac L, Im J, Thomas E, Coker C, et al.
Nat Commun
. 2024 Jan;
15(1):646.
PMID: 38245513
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment. Here, first, we demonstrate selective colonization of colorectal adenomas after oral delivery of probiotic E. coli...
6.
Ng J, Jafarov T, Little C, Wang T, Ali A, Ma Y, et al.
Nat Commun
. 2023 Nov;
14(1):6909.
PMID: 37907525
Osteoarthritis (OA) is characterised by an irreversible degeneration of articular cartilage. Here we show that the BMP-antagonist Gremlin 1 (Grem1) marks a bipotent chondrogenic and osteogenic progenitor cell population within...
7.
Thomas E, Wright J, Blake S, Page A, Worthley D, Woods S
Br J Cancer
. 2023 Aug;
129(9):1442-1450.
PMID: 37563222
Colorectal cancer (CRC) is a common and deadly disease. Unfortunately, immune checkpoint inhibitors (ICIs) fail to elicit effective anti-tumour responses in the vast majority of CRC patients. Patients that are...
8.
Cooper R, Wright J, Ng J, Goyne J, Suzuki N, Lee Y, et al.
Science
. 2023 Aug;
381(6658):682-686.
PMID: 37561843
Synthetic biology has developed sophisticated cellular biosensors to detect and respond to human disease. However, biosensors have not yet been engineered to detect specific extracellular DNA sequences and mutations. Here,...
9.
Gurbatri C, Radford G, Vrbanac L, Coker C, Im J, Taylor S, et al.
bioRxiv
. 2023 Apr;
PMID: 37066243
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral delivery...
10.
Ng J, Jafarov T, Little C, Wang T, Ali A, Ma Y, et al.
bioRxiv
. 2023 Apr;
PMID: 37034712
Osteoarthritis (OA), which carries an enormous disease burden across the world, is characterised by irreversible degeneration of articular cartilage (AC), and subsequently bone. The cellular cause of OA is unknown....