Daniel J Spakowicz
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Explore the profile of Daniel J Spakowicz including associated specialties, affiliations and a list of published articles.
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33
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1113
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Recent Articles
1.
Dynamic human gut microbiome and immune shifts during an immersive psychosocial intervention program
Zhou X, Ganz A, Rayner A, Cheng T, Oba H, Rolnik B, et al.
Brain Behav Immun
. 2024 Dec;
125:428-443.
PMID: 39701328
Background: Although depression is a leading cause of disability worldwide, the pathophysiological mechanisms underlying this disorder-particularly those involving the gut microbiome-are poorly understood. Method: To investigate, we conducted a community-based...
2.
Han C, Ning X, Burd C, Spakowicz D, Tounkara F, Kalady M, et al.
Cancers (Basel)
. 2024 Jul;
16(14).
PMID: 39061235
Background: Colorectal cancer (CRC) patients experience multiple types of chemotoxicity affecting treatment compliance, survival, and quality of life (QOL). Prior research shows clinician-reported chemotoxicity (i.e., grading scales or diagnostic codes)...
3.
Zhou X, Ganz A, Rayner A, Cheng T, Oba H, Rolnik B, et al.
bioRxiv
. 2024 Jul;
PMID: 38979211
Background: Depression is a leading cause of disability worldwide yet its underlying factors, particularly microbial associations, are poorly understood. Methods: We examined the longitudinal interplay between the microbiome and immune...
4.
Shantaram D, Hoyd R, Blaszczak A, Antwi L, Jalilvand A, Wright V, et al.
Nat Commun
. 2024 Jun;
15(1):5434.
PMID: 38937454
Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders. Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains more neutrophils than in those without obesity...
5.
Grogan M, Hoyd R, Benedict J, Janse S, Williams N, Naughton M, et al.
Front Aging
. 2024 Jun;
5:1268232.
PMID: 38911592
Introduction: Older adults with chronic disease prioritize functional independence. We aimed to describe the feasibility of capturing functional disability and treatment toxicity among older adults with lung cancer using a...
6.
Zhou X, Shen X, Johnson J, Spakowicz D, Agnello M, Zhou W, et al.
Cell Host Microbe
. 2024 Mar;
32(4):506-526.e9.
PMID: 38479397
To understand the dynamic interplay between the human microbiome and host during health and disease, we analyzed the microbial composition, temporal dynamics, and associations with host multi-omics, immune, and clinical...
7.
Zhou X, Shen X, Johnson J, Spakowicz D, Agnello M, Zhou W, et al.
bioRxiv
. 2024 Feb;
PMID: 38352363
Study Highlights: The stability of the human microbiome varies among individuals and body sites.Highly individualized microbial genera are more stable over time.At each of the four body sites, systematic interactions...
8.
Madison A, Burd C, Andridge R, Wilson S, Bailey M, Belury M, et al.
J Gerontol A Biol Sci Med Sci
. 2023 Dec;
79(3).
PMID: 38123141
Background: This study examined how gut microbiota diversity and richness relate to T cell aging among 96 healthy adults of all ages. It also explored whether these links differed throughout...
9.
Han C, Rosko A, Spakowicz D, Hammer M, Von Ah D
Qual Life Res
. 2023 Oct;
33(3):583-598.
PMID: 37897643
Purpose: Frailty in older adult cancer survivors after cancer treatments is associated with various health outcomes. However, there is less agreement on how frailty affects symptoms and health-related quality of...
10.
Hoyd R, Wheeler C, Liu Y, Jagjit Singh M, Muniak M, Jin N, et al.
Cancer Res Commun
. 2023 Oct;
3(11):2375-2385.
PMID: 37850841
Significance: The intrinsic tumor microbiome holds great potential for its ability to predict various aspects of cancer biology and as a target for rational manipulation. Here, we describe a tool...