Daniel J Leahy
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Explore the profile of Daniel J Leahy including associated specialties, affiliations and a list of published articles.
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Articles
75
Citations
5168
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Recent Articles
1.
Gonzalez-Magaldi M, Gullapalli A, Papoulas O, Liu C, Leung A, Guo L, et al.
bioRxiv
. 2024 Dec;
PMID: 39651119
Significance Statement: Atomic or near-atomic resolution structural studies of proteins embedded in cell membranes have proven challenging. We show that transporting integral membrane proteins to cell-derived extracellular vesicles enables structural...
2.
Kim S, Parker J, Gonzalez-Magaldi M, Telford M, Leahy D, Davies B
Appl Environ Microbiol
. 2023 Apr;
89(5):e0033523.
PMID: 37078870
Small proteins perform a diverse array of functions, from microbial competition, to endocrine signaling, to building biomaterials. Microbial systems that can produce recombinant small proteins enable discovery of new effectors,...
3.
Kim S, Parker J, Gonzalez-Magaldi M, Telford M, Leahy D, Davies B
bioRxiv
. 2023 Feb;
PMID: 36747863
Importance: Microcin type I secretion systems in Gram-negative bacteria transport antibacterial peptides from the cytoplasm to the extracellular environment in single step. In nature, each microcin secretion system is generally...
4.
Bartzoka F, Gonzalez-Magaldi M, Byrne P, Callery N, Hristova K, Leahy D
Biochem J
. 2022 Nov;
479(24):2465-2475.
PMID: 36416757
The Epidermal Growth Factor Receptor (EGFR) is a Receptor Tyrosine Kinase that mediates cell proliferation and differentiation events during development and maintenance of complex organisms. Formation of specific, ligand-dependent EGFR...
5.
Leahy D, Dalleck L, Ramos J
Front Sports Act Living
. 2022 Aug;
4:961957.
PMID: 35992158
Background: Many adults do not reach the recommended exercise participation guidelines, often citing lack of time as a barrier. Reduced exertion high-intensity training (REHIT) is a mode of exercise that...
6.
Gonzalez-Magaldi M, McCabe J, Cartwright H, Sun N, Leahy D
Biochem J
. 2020 Oct;
477(21):4207-4220.
PMID: 33043983
Receptor Tyrosine Kinases (RTKs) comprise a diverse group of cell-surface receptors that mediate key signaling events during animal development and are frequently activated in cancer. We show here that deletion...
7.
Byrne P, Hristova K, Leahy D
J Biol Chem
. 2020 Jul;
295(38):13353-13362.
PMID: 32727847
The human epidermal growth factor receptor (EGFR/ERBB1) is a receptor tyrosine kinase (RTK) that forms activated oligomers in response to ligand. Much evidence indicates that EGFR/ERBB1 also forms oligomers in...
8.
Lee C, Kim M, Li S, Leahy D, Coulombe P
Structure
. 2020 Jan;
28(3):355-362.e4.
PMID: 31995743
Intermediate filaments (IFs) provide vital mechanical support in a broad array of cell types. Interference with this role causes cell fragility and accounts for a large number of human diseases....
9.
Zhang W, Chuang Y, Na Y, Ye Z, Yang L, Lin R, et al.
Mol Cell
. 2019 Jun;
75(1):13-25.e5.
PMID: 31151856
Arc is a synaptic protein essential for memory consolidation. Recent studies indicate that Arc originates in evolution from a Ty3-Gypsy retrotransposon GAG domain. The N-lobe of Arc GAG domain acquired...
10.
Freed D, Bessman N, Kiyatkin A, Salazar-Cavazos E, Byrne P, Moore J, et al.
Cell
. 2017 Oct;
171(3):683-695.e18.
PMID: 28988771
Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways. Using crystallography and other approaches, we show how the...