Daniel J Ham
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Explore the profile of Daniel J Ham including associated specialties, affiliations and a list of published articles.
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33
Citations
512
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Recent Articles
1.
Mittal N, Ataman M, Tintignac L, Ham D, Jorin L, Schmidt A, et al.
NPJ Regen Med
. 2024 Sep;
9(1):23.
PMID: 39300171
Loss of protein homeostasis is one of the hallmarks of aging. As such, interventions that restore proteostasis should slow down the aging process and improve healthspan. Two of the most...
2.
Ataman M, Mittal N, Tintignac L, Schmidt A, Ham D, Gonzalez A, et al.
Commun Biol
. 2024 Aug;
7(1):974.
PMID: 39127848
Calorie restriction (CR) and treatment with rapamycin (RM), an inhibitor of the mTORC1 growth-promoting signaling pathway, are known to slow aging and promote health from worms to humans. At the...
3.
Cocchiararo I, Cattaneo O, Rajendran J, Chabry F, Cornut M, Soldati H, et al.
Hum Mol Genet
. 2023 Sep;
32(24):3374-3389.
PMID: 37756622
Defective lysosomal acidification is responsible for a large range of multi-systemic disorders associated with impaired autophagy. Diseases caused by mutations in the VMA21 gene stand as exceptions, specifically affecting skeletal...
4.
Kaiser M, Milan G, Ham D, Lin S, Oliveri F, Chojnowska K, et al.
Commun Biol
. 2022 Oct;
5(1):1141.
PMID: 36302954
Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates signals from growth factors, energy and amino acids to activate protein synthesis and inhibit protein breakdown. While mTORC1 activity is...
5.
Ham D, Borsch A, Chojnowska K, Lin S, Leuchtmann A, Ham A, et al.
Nat Commun
. 2022 Apr;
13(1):2410.
PMID: 35477974
No abstract available.
6.
Ham D, Borsch A, Chojnowska K, Lin S, Leuchtmann A, Ham A, et al.
Nat Commun
. 2022 Apr;
13(1):2025.
PMID: 35440545
Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie restriction (CR) potently extends health and lifespan, but is largely unachievable in humans, making "CR mimetics"...
7.
Borsch A, Ham D, Mittal N, Tintignac L, Migliavacca E, Feige J, et al.
Commun Biol
. 2021 Feb;
4(1):194.
PMID: 33580198
Sarcopenia, the age-related loss of skeletal muscle mass and function, affects 5-13% of individuals aged over 60 years. While rodents are widely-used model organisms, which aspects of sarcopenia are recapitulated...
8.
Castets P, Ham D, Ruegg M
Front Mol Neurosci
. 2020 Sep;
13:162.
PMID: 32982690
The neuromuscular junction (NMJ) is the chemical synapse connecting motor neurons and skeletal muscle fibers. NMJs allow all voluntary movements, and ensure vital functions like breathing. Changes in the structure...
9.
Ham D, Borsch A, Lin S, Thurkauf M, Weihrauch M, Reinhard J, et al.
Nat Commun
. 2020 Sep;
11(1):4510.
PMID: 32908143
With human median lifespan extending into the 80s in many developed countries, the societal burden of age-related muscle loss (sarcopenia) is increasing. mTORC1 promotes skeletal muscle hypertrophy, but also drives...
10.
Caldow M, Ham D, Trieu J, Chung J, Lynch G, Koopman R
Front Nutr
. 2019 Dec;
6:172.
PMID: 31803749
Glycine supplementation can protect skeletal muscles of mice from cancer-induced wasting, but the mechanisms underlying this protection are not well-understood. The aim of this study was to determine whether exogenous...