Daniel Insua
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Explore the profile of Daniel Insua including associated specialties, affiliations and a list of published articles.
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7
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75
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Recent Articles
1.
Lacosta A, Insua D, Badi H, Pesini P, Sarasa M
J Alzheimers Dis
. 2017 Apr;
58(3):661-667.
PMID: 28453491
The two pathognomonic lesions in the brain of AD patients are senile plaques and intraneuronal neurofibrillary tangles (NFT). Previous studies have demonstrated that amyloid-β (Aβ) is a component of both...
2.
Perez-Grijalba V, Fandos N, Canudas J, Insua D, Casabona D, Lacosta A, et al.
J Alzheimers Dis
. 2016 Aug;
54(2):751-62.
PMID: 27567833
Recent advances in neuroimaging and cerebrospinal fluid (CSF) biomarker assays have provided evidence of a long preclinical stage of Alzheimer's disease (AD). This period is being increasingly targeted for secondary...
3.
Canudas J, Insua D, Sarasa L, Gonzalez-Martinez A, Suarez M, Santamarina G, et al.
Int J Alzheimers Dis
. 2014 Feb;
2014:483281.
PMID: 24511411
Neprilysin (NEP) is the principal amyloid β (A β ) degrading peptidase; this activity may protect against Alzheimer's disease (AD), the most important age-related neurodegenerative process. The aim of this...
4.
Insua D, Corredoira A, Gonzalez-Martinez A, Suarez M, Santamarina G, Sarasa M, et al.
J Alzheimers Dis
. 2011 Oct;
28(2):291-6.
PMID: 21971402
The canine cognitive dysfunction syndrome (CDS) has been identified as a natural model for Alzheimer's disease (AD). We have used unbiased stereology to estimate the total number of basal forebrain...
5.
Bernedo V, Insua D, Suarez M, Santamarina G, Sarasa M, Pesini P
J Comp Neurol
. 2009 Jan;
513(4):417-29.
PMID: 19180552
Dogs may naturally suffer an age-related cognitive impairment that has aroused a great deal of interest, even beyond the field of the veterinary clinic. This canine senile dementia reproduces several...
6.
Insua D, Suarez M, Santamarina G, Sarasa M, Pesini P
Neurobiol Aging
. 2008 Jun;
31(4):625-35.
PMID: 18573571
Degeneration of noradrenergic neurons in the locus ceruleus is a well-described feature of Alzheimer's disease (AD). In spite of extensive utilization of the dog as a model for human degenerative...
7.
Menendez L, Insua D, Rois J, Santamarina G, Suarez M, Pesini P
J Chem Neuroanat
. 2006 Feb;
31(3):200-9.
PMID: 16488575
The present work describes for the first time the anatomical distribution of neuronal nitric oxide synthase (nNOS) immunoreactivity and NADPH-d activity in the basal forebrain of the dog. As in...