Daniel Ferguson
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Explore the profile of Daniel Ferguson including associated specialties, affiliations and a list of published articles.
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39
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Recent Articles
11.
Ferguson D, Eichler S, Yiew N, Colca J, Cho K, Patti G, et al.
Mol Metab
. 2023 Feb;
70:101694.
PMID: 36801448
Objective: The mitochondrial pyruvate carrier (MPC) has emerged as a therapeutic target for treating insulin resistance, type 2 diabetes, and nonalcoholic steatohepatitis (NASH). We evaluated whether MPC inhibitors (MPCi) might...
12.
LaPoint A, Singer J, Ferguson D, Shew T, Renkemeyer M, Palacios H, et al.
bioRxiv
. 2023 Feb;
PMID: 36778276
Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin 1 catalyzes the conversion...
13.
Martino M, Gutierrez-Aguilar M, Yiew N, Lutkewitte A, Singer J, McCommis K, et al.
Cell Rep
. 2022 Nov;
41(7):111633.
PMID: 36384117
No abstract available.
14.
Singer J, Shew T, Ferguson D, Renkemeyer M, Pietka T, Hall A, et al.
Obesity (Silver Spring)
. 2022 Nov;
30(11):2122-2133.
PMID: 36321276
Objective: Monoacylglycerol O-acyltransferase 1 (Mogat1), a lipogenic enzyme that converts monoacylglycerol to diacylglycerol, is highly expressed in adipocytes and may regulate lipolysis by re-esterifying fatty acids released during times when...
15.
Martino M, Gutierrez-Aguilar M, Yiew N, Lutkewitte A, Singer J, McCommis K, et al.
Cell Rep
. 2022 Apr;
39(4):110733.
PMID: 35476997
Hepatic gluconeogenesis from amino acids contributes significantly to diabetic hyperglycemia, but the molecular mechanisms involved are incompletely understood. Alanine transaminases (ALT1 and ALT2) catalyze the interconversion of alanine and pyruvate,...
16.
Schugar R, Gliniak C, Osborn L, Massey W, Sangwan N, Horak A, et al.
Elife
. 2022 Jan;
11.
PMID: 35072627
Obesity has repeatedly been linked to reorganization of the gut microbiome, yet to this point obesity therapeutics have been targeted exclusively toward the human host. Here, we show that gut...
17.
Hodges W, Jarasvaraparn C, Ferguson D, Griffett K, Gill L, Chen Y, et al.
J Biol Chem
. 2022 Jan;
298(2):101554.
PMID: 34973337
The mitochondrial pyruvate carrier (MPC) is an inner mitochondrial membrane complex that plays a critical role in intermediary metabolism. Inhibition of the MPC, especially in liver, may have efficacy for...
18.
Xie S, Metcalfe R, Mizutani H, Puhalovich T, Hanssen E, Morton C, et al.
Proc Natl Acad Sci U S A
. 2021 Sep;
118(39).
PMID: 34548400
The proteasome is a potential antimalarial drug target. We have identified a series of amino-amide boronates that are potent and specific inhibitors of the 20S proteasome (20S) β5 active site...
19.
Kalala B, Ferguson D, Nizeyimana F, Thakore S, Myukiyehe J, Twagirumugabi T, et al.
Can J Anaesth
. 2021 Aug;
68(11):1718-1720.
PMID: 34350558
No abstract available.
20.
Ferguson D, Finck B
Nat Rev Endocrinol
. 2021 Jun;
17(8):484-495.
PMID: 34131333
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease in the world, yet there are still no approved pharmacological therapies to prevent or treat this condition....