Daniel Eiler
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Explore the profile of Daniel Eiler including associated specialties, affiliations and a list of published articles.
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12
Citations
294
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Recent Articles
1.
Serrano C, Kanna Reddy H, Eiler D, Koch M, Tresco B, Barrows L, et al.
Angew Chem Int Ed Engl
. 2020 Apr;
59(28):11330-11333.
PMID: 32342623
In search of new anti-tuberculars compatible with anti-retroviral therapy we re-identified amicetin as a lead compound. Amicetin's binding to the 70S ribosomal subunit of Thermus thermophilus (Tth) has been unambiguously...
2.
Yesselman J, Eiler D, Carlson E, Gotrik M, dAquino A, Ooms A, et al.
Nat Nanotechnol
. 2019 Aug;
14(9):866-873.
PMID: 31427748
RNA nanotechnology seeks to create nanoscale machines by repurposing natural RNA modules. The field is slowed by the current need for human intuition during three-dimensional structural design. Here, we demonstrate...
3.
Akiyama B, Eiler D, Kieft J
Curr Opin Struct Biol
. 2016 Jan;
36:40-7.
PMID: 26797676
Cells contain powerful RNA decay machinery to eliminate unneeded RNA from the cell, and this process is an important and regulated part of controlling gene expression. However, certain structured RNAs...
4.
Englert M, Nakamura A, Wang Y, Eiler D, Soll D, Guo L
Nucleic Acids Res
. 2015 Nov;
43(22):11061-7.
PMID: 26582921
Genetically encoded non-canonical amino acids are powerful tools of protein research and engineering; in particular they allow substitution of individual chemical groups or atoms in a protein of interest. One...
5.
Guo L, Wang Y, Nakamura A, Eiler D, Kavran J, Wong M, et al.
Proc Natl Acad Sci U S A
. 2014 Nov;
111(47):16724-9.
PMID: 25385624
Pyrrolysyl-tRNA synthetase (PylRS) and its cognate tRNA(Pyl) have emerged as ideal translation components for genetic code innovation. Variants of the enzyme facilitate the incorporation >100 noncanonical amino acids (ncAAs) into...
6.
Eiler D, Wang J, Steitz T
Proc Natl Acad Sci U S A
. 2014 Aug;
111(36):13028-33.
PMID: 25157168
Twister is a recently discovered RNA motif that is estimated to have one of the fastest known catalytic rates of any naturally occurring small self-cleaving ribozyme. We determined the 4.1-Å...
7.
Eiler D, Lin J, Simonetti A, Klaholz B, Steitz T
Proc Natl Acad Sci U S A
. 2013 Sep;
110(39):15662-7.
PMID: 24029018
The initiation of protein synthesis uses initiation factor 2 (IF2) in prokaryotes and a related protein named eukaryotic initiation factor 5B (eIF5B) in eukaryotes. IF2 is a GTPase that positions...
8.
Simonetti A, Marzi S, Billas I, Tsai A, Fabbretti A, Myasnikov A, et al.
Proc Natl Acad Sci U S A
. 2013 Sep;
110(39):15656-61.
PMID: 24029017
Translation initiation factor 2 (IF2) promotes 30S initiation complex (IC) formation and 50S subunit joining, which produces the 70S IC. The architecture of full-length IF2, determined by small angle X-ray...
9.
Heinemann I, Nakamura A, ODonoghue P, Eiler D, Soll D
Nucleic Acids Res
. 2011 Sep;
40(1):333-44.
PMID: 21890903
Histidine transfer RNA (tRNA) is unique among tRNA species as it carries an additional nucleotide at its 5' terminus. This unusual G(-1) residue is the major tRNA(His) identity element, and...
10.
Saha S, Cai J, Eiler D, Hamilton A
Chem Commun (Camb)
. 2010 Feb;
46(10):1685-7.
PMID: 20177616
Guanine (G) rich G(4)T(4)G(4) DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5'-residues preferentially form parallel DNA quadruplex....