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Daniel E Speiser

Explore the profile of Daniel E Speiser including associated specialties, affiliations and a list of published articles. Areas
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Articles 221
Citations 11733
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Recent Articles
1.
Sun M, Garnier L, Chevalier R, Roumain M, Wang C, Angelillo J, et al.
Nat Commun . 2025 Jan; 16(1):1217. PMID: 39890772
In melanoma, lymphangiogenesis correlates with metastasis and poor prognosis and promotes immunosuppression. However, it also potentiates immunotherapy by supporting immune cell trafficking. We show in a lymphangiogenic murine melanoma that...
2.
Ackermann-Gaumann R, Dentand A, Lienhard R, Saeed M, Speiser D, MacDonald M, et al.
J Med Virol . 2024 Aug; 96(8):e29843. PMID: 39092814
Tick-borne encephalitis (TBE) virus is the most prevalent tick-transmitted orthoflavivirus in Europe. Due to the nonspecific nature of its symptoms, TBE is primarily diagnosed by ELISA-based detection of specific antibodies...
3.
Josi R, Speiser D, de Brot S, Vogt A, Sevick-Muraca E, Tolstonog G, et al.
iScience . 2024 Mar; 27(4):109439. PMID: 38523774
The global incidence of human papillomavirus (HPV) associated head and neck carcinoma is on the rise, in response to this a tetravalent therapeutic vaccine named Qβ-HPVag was developed. This vaccine,...
4.
Ferreira H, Stevenson B, Pak H, Yu F, Oliveira J, Huber F, et al.
Nat Commun . 2024 Mar; 15(1):2357. PMID: 38490980
Circular RNAs (circRNAs) are covalently closed non-coding RNAs lacking the 5' cap and the poly-A tail. Nevertheless, it has been demonstrated that certain circRNAs can undergo active translation. Therefore, aberrantly...
5.
Bachmann M, Vogel M, Speiser D
Vaccines (Basel) . 2023 Dec; 11(12). PMID: 38140255
The mechanisms of action of allergen-specific immunotherapy (AIT) are often referred to as the induction of 'tolerance'. However, immunological 'tolerance' is defined as an alteration in the function or composition...
6.
Franco F, Bevilacqua A, Wu R, Kao K, Lin C, Rousseau L, et al.
Sci Immunol . 2023 Sep; 8(87):eadf7579. PMID: 37738363
Mitophagy, a central process guarding mitochondrial quality, is commonly impaired in human diseases such as Parkinson's disease, but its impact in adaptive immunity remains unclear. The differentiation and survival of...
7.
Bobisse S, Bianchi V, Tanyi J, Sarivalasis A, Missiaglia E, Petremand R, et al.
Nat Cancer . 2023 Sep; 4(10):1410-1417. PMID: 37735588
We have previously shown that vaccination with tumor-pulsed dendritic cells amplifies neoantigen recognition in ovarian cancer. Here, in a phase 1 clinical study ( NCT01312376 /UPCC26810) including 19 patients, we...
8.
Ferretti L, Bohi F, Leslie Pedrioli D, Cheng P, Ferrari E, Baumgaertner P, et al.
Cancer Res . 2023 Sep; 83(23):3974-3988. PMID: 37729428
Significance: PARP inhibitors can overcome resistance to MAPK inhibitors by activating autophagic cell death and reversing phenotype switching, suggesting that this synergistic combination could help improve the prognosis of patients...
9.
Tille L, Cropp D, Charmoy M, Reichenbach P, Andreatta M, Wyss T, et al.
Nat Immunol . 2023 Sep; 24(10):1645-1653. PMID: 37709986
Persistent exposure to antigen during chronic infection or cancer renders T cells dysfunctional. The molecular mechanisms regulating this state of exhaustion are thought to be common in infection and cancer,...
10.
Romanens L, Chaskar P, Marcone R, Ryser S, Tille J, Genolet R, et al.
Int J Cancer . 2023 Jun; 153(9):1568-1578. PMID: 37306359
The spatial distribution of tumor-infiltrating lymphocytes (TIL) predicts breast cancer outcome and response to systemic therapy, highlighting the importance of an intact tissue structure for characterizing tumors. Here, we present...