Daniel D Hu
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Explore the profile of Daniel D Hu including associated specialties, affiliations and a list of published articles.
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12
Citations
33
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Recent Articles
1.
Wang Z, Liu Y, Safavisohi R, Asem M, Hu D, Stack M, et al.
bioRxiv
. 2024 Oct;
PMID: 39416176
Organs in the abdominal cavity are covered by a peritoneal membrane, which is comprised of a monolayer of mesothelial cells (MC). Diseases involving the peritoneal membrane include peritonitis, primary cancer...
2.
Jones B, Pareek V, Hu D, Weaver S, Syska C, Galfano G, et al.
bioRxiv
. 2024 Jul;
PMID: 39005365
Significance Statement: Acetylation is a modification of protein N-termini, lysine residues, antibiotics and lipids. Many of the enzymes that promote acetylation belong to the GNAT family of proteins. is a...
3.
Mousseau C, Hu D, Schultz S, Champion M
J Am Soc Mass Spectrom
. 2024 Jul;
35(8):2028-2031.
PMID: 38982799
Quenching digestions in proteomics prior to analysis is routine in order to eliminate residual protease activity. Residual activity leads to overdigestion, nonspecific star-activity, and back-exchange in isotopic O quantitation. Chemical...
4.
Avila-Cobian L, De Benedetti S, Hoshino H, Nguyen V, El-Araby A, Sader S, et al.
Protein Sci
. 2024 Jun;
33(7):e5038.
PMID: 38864725
Peptidoglycan is a major constituent of the bacterial cell wall. Its integrity as a polymeric edifice is critical for bacterial survival and, as such, it is a preeminent target for...
5.
Jones B, Hu D, Nicholson K, Cronin R, Weaver S, Champion M, et al.
mSphere
. 2024 Apr;
9(5):e0000524.
PMID: 38661343
The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors....
6.
Hu D, Weaver S, Collars O, Champion P, Champion M
Microbiol Resour Announc
. 2024 Mar;
13(4):e0126323.
PMID: 38477461
N-terminal acetylation in is correlated with pathogenic activity. We used genomics and bottom-up proteomics to identify protein Emp1 as the sole acetyltransferase responsible for acetylation of EsxA, a known virulence...
7.
Jones B, Hu D, Nicholson K, Cronin R, Champion M, Champion P
bioRxiv
. 2024 Jan;
PMID: 38260599
The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors....
8.
Collars O, Jones B, Hu D, Weaver S, Sherman T, Champion M, et al.
mBio
. 2023 Sep;
14(5):e0098723.
PMID: 37772840
N-terminal acetylation is a protein modification that broadly impacts basic cellular function and disease in higher organisms. Although bacterial proteins are N-terminally acetylated, little is understood how N-terminal acetylation impacts...
9.
Avila-Cobian L, Hoshino H, Horsman M, Nguyen V, Qian Y, Feltzer R, et al.
Protein Sci
. 2023 Sep;
32(10):e4781.
PMID: 37703013
The 11 lytic transglycosylases of Pseudomonas aeruginosa have overlapping activities in the turnover of the cell-wall peptidoglycan. Rare lipoprotein A (RlpA) is distinct among the 11 by its use of...
10.
Collars O, Jones B, Hu D, Weaver S, Champion M, Champion P
bioRxiv
. 2023 Mar;
PMID: 36993388
N-terminal protein acetylation is a ubiquitous post-translational modification that broadly impacts diverse cellular processes in higher organisms. Bacterial proteins are also N-terminally acetylated, but the mechanisms and consequences of this...