Daniel Blackstock
Overview
Explore the profile of Daniel Blackstock including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
70
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Recent Articles
1.
Gollapudi D, Rosales-Zavala E, Ivleva V, Yang Y, Li Y, OConnell S, et al.
Biotechnol Prog
. 2022 Sep;
38(6):e3296.
PMID: 36054677
Broadly neutralizing antibody (bNAb) CAP256-VRC26.25 (abbreviated CAP256LS), a human IgGI monoclonal antibody targeting the V1V2 site of the HIV-1 envelope, has demonstrated high therapeutic potential as a broadly neutralizing monoclonal...
2.
Cai C, Doria-Rose N, Schneck N, Ivleva V, Tippett B, Shadrick W, et al.
Sci Rep
. 2022 May;
12(1):8433.
PMID: 35589938
CAP256V2LS, a broadly neutralizing monoclonal antibody (bNAb), is being pursued as a promising drug for HIV-1 prevention. The total level of tyrosine-O-sulfation, a post-translational modification, was known to play a...
3.
Cai C, Schneck N, Zhao W, Blackstock D, Cai J, Harris D, et al.
Anal Bioanal Chem
. 2019 Aug;
411(23):6111-6118.
PMID: 31367804
Application of a protease inhibitor, 4-(2-aminoethyl) benzenesulfonyl fluoride (AEBSF), during the cell culture process was demonstrated to effectively reduce proteolytic activity at a specific amino acid site during the production...
4.
Hong J, Demirji J, Blackstock D, Lee J, Dinh T, Goh A, et al.
Biotechnol Prog
. 2019 May;
35(5):e2831.
PMID: 31050215
An alternating tangential flow (ATF) perfusion-based transient gene expression (TGE) bioprocess has been developed using human embryonic kidney (HEK) 293 cells to produce H1-ss-np, a promising candidate for a universal...
5.
Cai C, Schneck N, Harris D, Blackstock D, Ivleva V, Cheng K, et al.
J Chromatogr B Analyt Technol Biomed Life Sci
. 2019 Apr;
1116:19-23.
PMID: 30953918
During research of a broadly neutralizing antibody (bNAb) for HIV-1 infection, site-specific clipping was observed during cell culture incubation. Protease inhibitor, 4-(2-aminoethyl) benzenesulfonyl fluoride (AEBSF), was supplemented to the cell...
6.
Chen R, Blackstock D, Sun Q, Chen W
Nat Chem
. 2018 Mar;
10(4):474-481.
PMID: 29531373
Inspired by the remarkable ability of natural protein switches to sense and respond to a wide range of environmental queues, here we report a strategy to engineer synthetic protein switches...
7.
Huang J, Nagy A, Ivleva V, Blackstock D, Arnold F, Cai C
Anal Chem
. 2018 Mar;
90(7):4293-4296.
PMID: 29508618
One approach to mitigate product clipping during HIV mAb CAP256-VRC26.25 cell-culture development is the addition of the protease inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride (AEBSF) to the cell-culture media. AEBSF can undergo...
8.
Sun Q, Chen Q, Blackstock D, Chen W
ACS Nano
. 2015 Aug;
9(8):8554-61.
PMID: 26235232
Context driven biosensor assembly with modular targeting and detection moieties is gaining significant attentions. Although protein-based nanoparticles have emerged as an excellent platform for biosensor assembly, current strategies of decorating...
9.
Blackstock D, Chen W
Chem Commun (Camb)
. 2014 Sep;
50(89):13735-8.
PMID: 25248640
We report here the generation of a fluorescent protein (FP)-based dual molecular beacon (MB) system for nucleic acid detection. Halo-tag mediated conjugation was used for the site-specific decoration of MBs...
10.
Blackstock D, Sun Q, Chen W
Biotechnol Bioeng
. 2014 Aug;
112(2):236-41.
PMID: 25163615
Molecular beacons (MBs) are stem-loop structured oligonucleotides capable of sensitive and specific nucleic acid detection. However, large-scale usage of MBs for high throughput applications has been hindered by the many...