Daniel B Polley
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Explore the profile of Daniel B Polley including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Asokan M, Watanabe Y, Kimchi E, Polley D
bioRxiv
. 2023 Feb;
PMID: 36778308
Reappraising neutral stimuli as environmental threats reflects rapid and discriminative changes in sensory processing within the basolateral amygdala (BLA). To understand how BLA inputs are also reorganized during discriminative threat...
12.
McGill M, Hight A, Watanabe Y, Parthasarathy A, Cai D, Clayton K, et al.
Elife
. 2022 Sep;
11.
PMID: 36111669
Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates despite large fluctuations in afferent activity levels. However, sudden peripheral deafferentation in adulthood can trigger an excessive,...
13.
J Smalt C, Sugai J, Koops E, Jahn K, Hancock K, Polley D
NPJ Digit Med
. 2022 Aug;
5(1):127.
PMID: 36038708
Tinnitus, or ringing in the ears, is a prevalent condition that imposes a substantial health and financial burden on the patient and to society. The diagnosis of tinnitus, like pain,...
14.
Grant K, Parthasarathy A, Vasilkov V, Caswell-Midwinter B, Freitas M, de Gruttola V, et al.
Sci Rep
. 2022 Jun;
12(1):8929.
PMID: 35739134
The current gold standard of clinical hearing assessment includes a pure-tone audiogram combined with a word recognition task. This retrospective study tests the hypothesis that deficits in word recognition that...
15.
Jahn K, Hancock K, Maison S, Polley D
JASA Express Lett
. 2022 Jun;
2(6):064403.
PMID: 35719240
In animal models, cochlear neural degeneration (CND) is associated with excess central gain and hyperacusis, but a compelling link between reduced cochlear neural inputs and heightened loudness perception in humans...
16.
Polley D, Schiller D
Neurosci Biobehav Rev
. 2022 Apr;
137:104652.
PMID: 35385759
As an academic pursuit, neuroscience is enjoying a golden age. From a clinical perspective, our field is failing. Conventional 20th century drugs and devices are not well-matched to the heterogeneity,...
17.
Robert B, Kimchi E, Watanabe Y, Chakoma T, Jing M, Li Y, et al.
Elife
. 2021 Nov;
10.
PMID: 34821218
Basal forebrain cholinergic neurons (BFCNs) project throughout the cortex to regulate arousal, stimulus salience, plasticity, and learning. Although often treated as a monolithic structure, the basal forebrain features distinct connectivity...
18.
Clayton K, Asokan M, Watanabe Y, Hancock K, Polley D
Front Neurosci
. 2021 Jul;
15:666627.
PMID: 34305516
The massive network of descending corticofugal projections has been long-recognized by anatomists, but their functional contributions to sound processing and auditory-guided behaviors remain a mystery. Most efforts to characterize the...
19.
Asokan M, Williamson R, Hancock K, Polley D
Curr Biol
. 2021 Feb;
31(8):1762-1770.e4.
PMID: 33609455
In sensory systems, representational features of increasing complexity emerge at successive stages of processing. In the mammalian auditory pathway, the clearest change from brainstem to cortex is defined by what...
20.
Resnik J, Polley D
Neuron
. 2021 Feb;
109(6):984-996.e4.
PMID: 33561398
Correlational evidence in humans suggests that selective difficulties hearing in noisy, social settings may reflect premature auditory nerve degeneration. Here, we induced primary cochlear neural degeneration (CND) in adult mice...