Daniel A Thomas
Overview
Explore the profile of Daniel A Thomas including associated specialties, affiliations and a list of published articles.
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43
Citations
811
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Recent Articles
1.
Lay C, Thomas D, Evans J, Campbell M, McCombe K, Phillipou A, et al.
Cell Chem Biol
. 2023 Dec;
30(12):1692.
PMID: 38134882
No abstract available.
2.
Taccone M, Thomas D, Ober K, Gewinner S, Schollkopf W, Meijer G, et al.
Phys Chem Chem Phys
. 2023 Apr;
25(15):10907-10916.
PMID: 37014635
Hydrogen bonding interactions are essential in the structural stabilization and physicochemical properties of complex molecular systems, and carboxylic acid functional groups are common participants in these motifs. Consequently, the neutral...
3.
Schultz M, Parker S, Fernando M, Wellalage M, Thomas D
J Am Soc Mass Spectrom
. 2023 Mar;
34(4):745-753.
PMID: 36975839
Transferring biomolecules from solution to vacuum facilitates a detailed analysis of molecular structure and dynamics by isolating molecules of interest from a complex environment. However, inherent in the ion desolvation...
4.
Lay C, Thomas D, Evans J, Jones E, Gatfield K, Craggs P
STAR Protoc
. 2022 Jan;
3(1):101078.
PMID: 35059653
The Kinetic Intra-Cellular Assay (KICA) is a recombinant cell-based technique that utilizes NanoBRET technology. KICA enables the measurement of intracellular binding kinetics. This protocol describes steps for cellular transfection and...
5.
Wellaway C, Baldwin I, Bamborough P, Barker D, Bartholomew M, Chung C, et al.
J Med Chem
. 2021 Dec;
65(1):633-664.
PMID: 34928601
The Janus family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) play an essential role in the receptor signaling of cytokines that have been implicated in the pathogenesis of severe...
6.
Thomas D, Taccone M, Ober K, Mucha E, Meijer G, von Helden G
J Phys Chem A
. 2021 Oct;
125(42):9279-9287.
PMID: 34652165
The proton-bound dimer of hydrogen sulfate and formate is an archetypal structure for ionic hydrogen-bonding complexes that contribute to biogenic aerosol nucleation. Of central importance for the structure and properties...
7.
Lay C, Thomas D, Evans J, Campbell M, McCombe K, Phillipou A, et al.
Cell Chem Biol
. 2021 Sep;
29(2):287-299.e8.
PMID: 34520747
Contemporary drug discovery typically quantifies the effect of a molecule on a biological target using the equilibrium-derived measurements of IC, EC, or K. Kinetic descriptors of drug binding are frequently...
8.
Down K, Amour A, Anderson N, Barton N, Campos S, Cannons E, et al.
J Med Chem
. 2021 Sep;
64(18):13780-13792.
PMID: 34510892
Optimization of a previously reported lead series of PI3Kδ inhibitors with a novel binding mode led to the identification of a clinical candidate compound (GSK251). Removal of an embedded Ames-positive...
9.
Fournier J, Evans J, Zappacosta F, Thomas D, Patel V, White G, et al.
ACS Chem Biol
. 2021 Aug;
16(9):1644-1653.
PMID: 34397208
Covalent inhibition is a powerful strategy to develop potent and selective small molecule kinase inhibitors. Targeting the conserved catalytic lysine is an attractive method for selective kinase inactivation. We have...
10.
Thomas D, Chang R, Mucha E, Lettow M, Greis K, Gewinner S, et al.
Phys Chem Chem Phys
. 2020 Aug;
22(33):18400-18413.
PMID: 32797142
Isolation of biomolecules in vacuum facilitates characterization of the intramolecular interactions that determine three-dimensional structure, but experimental quantification of conformer thermochemistry remains challenging. Infrared spectroscopy of molecules trapped in helium...