Daniel A McNaughton
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Explore the profile of Daniel A McNaughton including associated specialties, affiliations and a list of published articles.
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8
Citations
15
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Recent Articles
1.
Maslowska-Jarzyna K, Rooijmans S, McNaughton D, Ryder W, York E, Tromp M, et al.
Chem Commun (Camb)
. 2025 Feb;
61(21):4184-4187.
PMID: 39960460
A potent squaramide-based anion transporter was used to evaluate how vesicles prepared with tailored lipid compositions, which mimic organelle membranes, can impact transmembrane transport. Using HPTS and ISE assays, we...
2.
Li J, Catal O, Marques I, McNaughton D, Maklad R, Ryder W, et al.
J Am Chem Soc
. 2025 Jan;
147(4):3392-3401.
PMID: 39805740
Designing molecular receptors that bind anions in water is a significant challenge, and an even greater difficulty lies in using these receptors to remove anions from water without resorting to...
3.
York E, McNaughton D, Gertner D, Gale P, Murray M, Rawling T
Chemistry
. 2024 Jun;
30(46):e202400931.
PMID: 38838073
Mitochondrial uncoupling by small molecule protonophores is a promising strategy for developing novel anticancer agents. Recently, aryl urea substituted fatty acids (aryl ureas) were identified as a new class of...
4.
McNaughton D, York E, Rawling T, Gale P
Org Biomol Chem
. 2024 May;
22(24):4868-4876.
PMID: 38764358
The ,'-dimethylation of a diphenylsquaramide induces a conformational change in the orientation of the phenyl rings. This has been exploited to create a series of bis-urea, -thiourea and -squaramide anionophores....
5.
Park S, Hwang I, McNaughton D, Kinross A, Howe E, He Q, et al.
Chem
. 2024 Jan;
7(12):3325-3339.
PMID: 38239771
A number of artificial cation ionophores (or transporters) have been developed for basic research and biomedical applications. However, their mechanisms of action and the putative correlations between changes in intracellular...
6.
York E, McNaughton D, Duman M, Gale P, Rawling T
Biomolecules
. 2023 Aug;
13(8).
PMID: 37627266
In respiring mitochondria, the proton gradient across the inner mitochondrial membrane is used to drive ATP production. Mitochondrial uncouplers, which are typically weak acid protonophores, can disrupt this process to...
7.
Fares M, Wu X, McNaughton D, Gilchrist A, Lewis W, Keller P, et al.
Org Biomol Chem
. 2023 Mar;
21(12):2509-2515.
PMID: 36880402
A series of fluorescent coumarin bis-ureas 1-4 have been synthesised, and their anion transport properties studied. The compounds function as highly potent HCl co-transport agents in lipid bilayer membranes. Single...
8.
York E, McNaughton D, Roseblade A, Cranfield C, Gale P, Rawling T
ACS Chem Biol
. 2022 Jul;
17(8):2065-2073.
PMID: 35854216
Targeting the cancer cell mitochondrion is a promising approach for developing novel anticancer agents. The experimental anticancer agent ,'-bis(3,5-dichlorophenyl)urea () induces apoptotic cell death in several cancer cell lines by...
9.
McNaughton D, To T, Hawkins B, Hibbs D, Gale P
Org Biomol Chem
. 2021 Oct;
19(44):9624-9628.
PMID: 34709282
Cyclodextrins have been employed as delivery agents for lipophilic anion transporters, which allow their incorporation into lipid bilayers without using an organic solvent or pre-incorporation.
10.
McNaughton D, Macreadie L, Gale P
Org Biomol Chem
. 2021 Sep;
19(44):9659-9674.
PMID: 34515286
The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven to be a successful strategy in the development of potent chloride transporters. In this work, we revisit...