Daniel A Keedy
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Explore the profile of Daniel A Keedy including associated specialties, affiliations and a list of published articles.
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35
Citations
10959
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Recent Articles
11.
Sharma S, Mehlman T, Sagabala R, Boivin B, Keedy D
Acta Crystallogr F Struct Biol Commun
. 2023 Dec;
80(Pt 1):1-12.
PMID: 38133579
Protein tyrosine phosphatase 1B (PTP1B) plays important roles in cellular homeostasis and is a highly validated therapeutic target for multiple human ailments, including diabetes, obesity and breast cancer. However, much...
12.
Woods V, Abzalimov R, Keedy D
bioRxiv
. 2023 Jul;
PMID: 37503000
Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for obesity, diabetes, and certain types of cancer. In particular, allosteric inhibitors hold potential for therapeutic use, but an incomplete...
13.
Wankowicz S, Ravikumar A, Sharma S, Riley B, Raju A, Flowers J, et al.
bioRxiv
. 2023 Jul;
PMID: 37425870
In their folded state, biomolecules exchange between multiple conformational states that are crucial for their function. Traditional structural biology methods, such as X-ray crystallography and cryogenic electron microscopy (cryo-EM), produce...
14.
Guerrero L, Ebrahim A, Riley B, Kim M, Huang Q, Finke A, et al.
bioRxiv
. 2023 May;
PMID: 37205580
Protein function hinges on small shifts of three-dimensional structure. Elevating temperature or pressure may provide experimentally accessible insights into such shifts, but the effects of these distinct perturbations on protein...
15.
Mehlman T, Biel J, Azeem S, Nelson E, Hossain S, Dunnett L, et al.
Elife
. 2023 Mar;
12.
PMID: 36881464
Much of our current understanding of how small-molecule ligands interact with proteins stems from X-ray crystal structures determined at cryogenic (cryo) temperature. For proteins alone, room-temperature (RT) crystallography can reveal...
16.
Sharma S, Ebrahim A, Keedy D
Acta Crystallogr F Struct Biol Commun
. 2023 Jan;
79(Pt 1):23-30.
PMID: 36598353
Room-temperature X-ray crystallography provides unique insights into protein conformational heterogeneity, but obtaining sufficiently large protein crystals is a common hurdle. Serial synchrotron crystallography (SSX) helps to address this hurdle by...
17.
Ebrahim A, Riley B, Kumaran D, Andi B, Fuchs M, McSweeney S, et al.
IUCrJ
. 2022 Sep;
9(Pt 5):682-694.
PMID: 36071812
The COVID-19 pandemic, instigated by the SARS-CoV-2 coronavirus, continues to plague the globe. The SARS-CoV-2 main protease, or M, is a promising target for the development of novel antiviral therapeutics....
18.
Ebrahim A, Riley B, Kumaran D, Andi B, Fuchs M, McSweeney S, et al.
bioRxiv
. 2021 May;
PMID: 33972941
The COVID-19 pandemic, instigated by the SARS-CoV-2 coronavirus, continues to plague the globe. The SARS-CoV-2 main protease, or M, is a promising target for development of novel antiviral therapeutics. Previous...
19.
Riley B, Wankowicz S, P de Oliveira S, van Zundert G, Hogan D, Fraser J, et al.
Protein Sci
. 2020 Nov;
30(1):270-285.
PMID: 33210433
New X-ray crystallography and cryo-electron microscopy (cryo-EM) approaches yield vast amounts of structural data from dynamic proteins and their complexes. Modeling the full conformational ensemble can provide important biological insights,...
20.
Keedy D
Acta Crystallogr D Struct Biol
. 2019 Mar;
75(Pt 2):123-137.
PMID: 30821702
Proteins inherently fluctuate between conformations to perform functions in the cell. For example, they sample product-binding, transition-state-stabilizing and product-release states during catalysis, and they integrate signals from remote regions of...