Daniel A Keedy
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Explore the profile of Daniel A Keedy including associated specialties, affiliations and a list of published articles.
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35
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10959
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Recent Articles
1.
Wu J, Baranowski M, Aleshin A, Isiorho E, Lambert L, De Backer L, et al.
ACS Omega
. 2025 Feb;
10(5):4912-4926.
PMID: 39959108
The human H1-related phosphatase (VHR; ) is a critical positive regulator of the innate immune response. Recent studies suggest that inhibiting VHR could be beneficial in treating sepsis and septic...
2.
Chartier C, Woods V, Xu Y, van Vlimmeren A, Johns A, Jovanovic M, et al.
Protein Sci
. 2024 Dec;
34(1):e70016.
PMID: 39723820
The rapid identification of protein-protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and proximity-labeling proteomics. While these methods can reveal networks of...
3.
Guerrero L, Ebrahim A, Riley B, Kim S, Bishop A, Wu J, et al.
bioRxiv
. 2024 Nov;
PMID: 39605455
Protein tyrosine phosphatases (PTPs) play pivotal roles in myriad cellular processes by counteracting protein tyrosine kinases. Striatal-enriched protein tyrosine phosphatase (STEP, PTPN5) regulates synaptic function and neuronal plasticity in the...
4.
Perdikari A, Woods V, Ebrahim A, Lawler K, Bounds R, Singh N, et al.
bioRxiv
. 2024 Aug;
PMID: 39149290
Protein Tyrosine Phosphatase 1B (PTP1B) is a negative regulator of leptin signaling whose disruption protects against diet-induced obesity in mice. We investigated whether structural characterization of human PTP1B variant proteins...
5.
Chartier C, Woods V, Xu Y, van Vlimmeren A, Johns A, Jovanovic M, et al.
bioRxiv
. 2024 Jul;
PMID: 39071364
The rapid identification of protein-protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and proximity-labeling proteomics. While these methods can reveal networks of...
6.
Wankowicz S, Ravikumar A, Sharma S, Riley B, Raju A, Hogan D, et al.
Elife
. 2024 Jun;
12.
PMID: 38904665
In their folded state, biomolecules exchange between multiple conformational states that are crucial for their function. Traditional structural biology methods, such as X-ray crystallography and cryogenic electron microscopy (cryo-EM), produce...
7.
Mehlman T, Ginn H, Keedy D
Structure
. 2024 Jun;
32(8):1231-1238.e4.
PMID: 38861991
Due to their low binding affinities, detecting small-molecule fragments bound to protein structures from crystallographic datasets has been a challenge. Here, we report a trove of 65 new fragment hits...
8.
Woods V, Abzalimov R, Keedy D
Protein Sci
. 2024 May;
33(6):e5024.
PMID: 38801229
Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for obesity, diabetes, and certain types of cancer. In particular, allosteric inhibitors hold potential for therapeutic use, but an incomplete...
9.
Mehlman T, Ginn H, Keedy D
bioRxiv
. 2024 Jan;
PMID: 38260327
The recent advent of crystallographic small-molecule fragment screening presents the opportunity to obtain unprecedented numbers of ligand-bound protein crystal structures from a single high-throughput experiment, mapping ligandability across protein surfaces...
10.
Guerrero L, Ebrahim A, Riley B, Kim M, Huang Q, Finke A, et al.
Commun Biol
. 2024 Jan;
7(1):59.
PMID: 38216663
Protein function hinges on small shifts of three-dimensional structure. Elevating temperature or pressure may provide experimentally accessible insights into such shifts, but the effects of these distinct perturbations on protein...