Dan-Dan Shen
Overview
Explore the profile of Dan-Dan Shen including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
63
Citations
1918
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ma X, Chen L, Liao M, Zhang L, Xi K, Guo J, et al.
Nat Commun
. 2024 Dec;
15(1):10601.
PMID: 39638804
The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large extracellular region, plays a pivotal role in auditory function through G. Here, we firstly demonstrate that GPR156 with...
2.
Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, et al.
Nat Commun
. 2024 Nov;
15(1):10345.
PMID: 39609406
The structural basis for the allosteric interactions within G protein-coupled receptors (GPCRs) heterodimers remains largely unknown. The metabotropic glutamate (mGlu) receptors are complex dimeric GPCRs important for the fine tuning...
3.
Shen D, Zhang Y, Li X, Bai Y, Xiong J, Seng D, et al.
Drug Dev Res
. 2024 Sep;
85(6):e22260.
PMID: 39254376
In 2023, the U.S. Food and Drug Administration has approved 29 small molecule drugs. These newly approved small molecule drugs possess the distinct scaffolds, thereby exhibiting diverse mechanisms of action...
4.
Bai Y, Yang W, Jia R, Sun J, Shen D, Liu H, et al.
Med Res Rev
. 2024 Aug;
45(1):214-273.
PMID: 39180380
Chemotherapies are commonly used in cancer therapy, their applications are limited to low specificity, severe adverse reactions, and long-term medication-induced drug resistance. Poly(ADP-ribose) polymerase (PARP) inhibitors are a novel class...
5.
Mamun M, Zheng Y, Wang N, Wang B, Zhang Y, Pang J, et al.
Int Immunopharmacol
. 2024 Jun;
137:112355.
PMID: 38851158
One major obstacle in the treatment of cancer is the presence of proteins resistant to cancer therapy, which can impede the effectiveness of traditional approaches such as radiation and chemotherapy....
6.
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang S, et al.
Adv Sci (Weinh)
. 2024 Apr;
11(23):e2310120.
PMID: 38647423
G-protein-coupled receptors (GPCRs) transmit downstream signals predominantly via G-protein pathways. However, the conformational basis of selective coupling of primary G-protein remains elusive. Histamine receptors HR and HR couple with G-...
7.
Wang W, Ji S, Zhang W, Zhang J, Cai C, Hu R, et al.
Cell
. 2024 Mar;
187(6):1460-1475.e20.
PMID: 38428423
Apelin is a key hormone in cardiovascular homeostasis that activates the apelin receptor (APLNR), which is regarded as a promising therapeutic target for cardiovascular disease. However, adverse effects through the...
8.
Li R, Yang Y, Qiao L, Yang L, Shen D, Zhao X
Biomed Pharmacother
. 2024 Jan;
171:116173.
PMID: 38237349
Backgrounds: Poorly regulated mitosis and chromosomal instability are common characteristics in malignant tumor cells. Kinesin family member 2 C (KIF2C), also known as mitotic centromere-associated kinesin (MCAK) is an essential...
9.
Mao C, Zhao R, Dong Y, Gao M, Chen L, Zhang C, et al.
Mol Cell
. 2024 Jan;
84(3):570-583.e7.
PMID: 38215752
Adhesion G protein-coupled receptors (aGPCRs) are evolutionarily ancient receptors involved in a variety of physiological and pathophysiological processes. Modulators of aGPCR, particularly antagonists, hold therapeutic promise for diseases like cancer...
10.
Liao Y, Zhang H, Shen Q, Cai C, Ding Y, Shen D, et al.
Cell
. 2023 Dec;
186(26):5784-5797.e17.
PMID: 38101408
Cannabis activates the cannabinoid receptor 1 (CB1), which elicits analgesic and emotion regulation benefits, along with adverse effects, via G and β-arrestin signaling pathways. However, the lack of understanding of...