Daizo Koinuma
Overview
Explore the profile of Daizo Koinuma including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
1788
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Recent Articles
1.
Shinozaki-Ushiku A, Koinuma D, Nakayama A, Nawa J, Fujishiro M, Ushiku T
Mod Pathol
. 2025 Jan;
38(5):100719.
PMID: 39863113
Oxyntic gland neoplasms typically arise in Helicobacter pylori-naive stomachs and are composed predominantly of chief cells, with a smaller component of parietal cells. Their pathologic diagnosis can be challenging owing...
2.
Itoh Y, Miyake K, Koinuma D, Omata C, Saitoh M, Miyazawa K
FASEB J
. 2024 Aug;
38(15):e23877.
PMID: 39114961
Transforming growth factor-β (TGF-β) is a pleiotropic cytokine that modulates a wide variety of cellular responses by regulating target gene expression. It principally transmits signals via receptor-activated transcription factors Smad2...
3.
Kondo A, Shinozaki-Ushiku A, Rokutan H, Kunita A, Ikemura M, Yamashita H, et al.
J Pathol
. 2023 Feb;
260(2):124-136.
PMID: 36806225
Epstein-Barr virus (EBV) is one of the major drivers of gastric carcinogenesis. EBV infection is established before tumour initiation and is generally maintained throughout tumour development; however, the significance of...
4.
Takahashi K, Podyma-Inoue K, Saito M, Sakakitani S, Sugauchi A, Iida K, et al.
Cell Rep
. 2022 Sep;
40(13):111411.
PMID: 36170816
Transforming growth factor β (TGF-β) increases epithelial cancer cell migration and metastasis by inducing epithelial-mesenchymal transition (EMT). TGF-β also inhibits cell proliferation by inducing G1 phase cell-cycle arrest. However, the...
5.
Ogami T, Tamura Y, Toss K, Yuki K, Morikawa M, Tsutsumi S, et al.
J Biochem
. 2021 Dec;
171(4):399-410.
PMID: 34908107
Smad proteins transduce signals downstream of transforming growth factor-β (TGF-β) and are one of the factors that regulate the expression of genes related to diseases affecting the skin. In the...
6.
Tamura Y, Tsutsumi S, Miyazono K, Koinuma D
Cancer Sci
. 2021 Dec;
113(3):940-949.
PMID: 34897916
The activation of RIG-I-like receptor (RLR) signaling in cancer cells is widely recognized as a critical cancer therapy method. The expected mechanism of RLR ligand-mediated cancer therapy involves the promotion...
7.
Fukuda T, Fukuda R, Koinuma D, Moustakas A, Miyazono K, Heldin C
Cell Signal
. 2021 Sep;
87:110146.
PMID: 34517088
We previously reported that bone morphogenetic protein (BMP) signaling promotes tumorigenesis in gynecologic cancer cells. BMP2 enhances proliferation of ovarian and endometrial cancer cells via c-KIT induction, and triggers epithelial-mesenchymal...
8.
Tanabe R, Miyazono K, Todo T, Saito N, Iwata C, Komuro A, et al.
Mol Oncol
. 2021 Jul;
16(1):269-288.
PMID: 34214250
Glioma-initiating cells (GICs), a major source of glioblastoma recurrence, are characterized by the expression of neural stem cell markers and the ability to grow by forming nonadherent spheres under serum-free...
9.
Miyakuni K, Nishida J, Koinuma D, Nagae G, Aburatani H, Miyazono K, et al.
Mol Oncol
. 2021 Jun;
16(3):732-749.
PMID: 34133843
DNA hypermethylation is frequently observed in clear cell renal cell carcinoma (ccRCC) and correlates with poor clinical outcomes. However, the detailed function of DNA hypermethylation in ccRCC has not been...
10.
Ozawa T, Morikawa M, Morishita Y, Ogikubo K, Itoh F, Koinuma D, et al.
iScience
. 2021 Jun;
24(5):102488.
PMID: 34113826
Targeting the signaling pathway of growth differentiation factor 8 (GDF8), also known as myostatin, has been regarded as a promising strategy to increase muscle mass in the elderly and in...