D W Hilgemann
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Explore the profile of D W Hilgemann including associated specialties, affiliations and a list of published articles.
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41
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2382
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Recent Articles
1.
Hilgemann D, Feng S, Nasuhoglu C
Sci STKE
. 2001 Dec;
2001(111):re19.
PMID: 11734659
Phosphatidylinositol-4,5-bisphosphate (PIP(2)), the precursor of several signaling molecules in eukayotic cells, is itself also used by cells to signal to membrane-associated proteins. PIP(2) anchors numerous signaling molecules and cytoskeleton at...
2.
Womack K, Gordon S, He F, Wensel T, Lu C, Hilgemann D
J Neurosci
. 2001 Feb;
20(8):2792-9.
PMID: 10751430
Mammalian rod cyclic nucleotide gated (CNG) channels (i.e., alpha plus beta subunits) are strongly inhibited by phosphatidylinositol 4, 5-bisphosphate (PIP(2)) when they are expressed in Xenopus oocytes and studied in...
3.
He Z, Feng S, Tong Q, Hilgemann D, Philipson K
Am J Physiol Cell Physiol
. 2001 Feb;
278(4):C661-6.
PMID: 10751315
The sarcolemmal Na/Ca exchanger undergoes an inactivation process in which exchange activity decays over several seconds following activation by the application of Na to the intracellular surface of the protein....
4.
Hilgemann D, Lu C
J Gen Physiol
. 1999 Sep;
114(3):459-75.
PMID: 10469735
We have developed an alternating access transport model that accounts well for GAT1 (GABA:Na+:Cl-) cotransport function in Xenopus oocyte membranes. To do so, many alternative models were fitted to a...
5.
Lu C, Hilgemann D
J Gen Physiol
. 1999 Sep;
114(3):445-57.
PMID: 10469734
To explain cotransport function, the "alternating access" model requires that conformational changes of the empty transporter allow substrates to bind alternatively on opposite membrane sides. To test this principle for...
6.
Lu C, Hilgemann D
J Gen Physiol
. 1999 Sep;
114(3):429-44.
PMID: 10469733
Neurotransmitter transporters are reported to mediate transmembrane ion movements that are poorly coupled to neurotransmitter transport and to exhibit complex "channel-like" behaviors that challenge the classical "alternating access" transport model....
7.
Shaul O, Hilgemann D, Van Montagu M, Inz D, Galili G
EMBO J
. 1999 Jul;
18(14):3973-80.
PMID: 10406802
Cellular functions require adequate homeostasis of several divalent metal cations, including Mg(2+) and Zn(2+). Mg(2+), the most abundant free divalent cytoplasmic cation, is essential for many enzymatic reactions, while Zn(2+)...
8.
9.
He Z, Tong Q, Quednau B, Philipson K, Hilgemann D
J Gen Physiol
. 1998 Jun;
111(6):857-73.
PMID: 9607941
We have cloned the squid neuronal Na+-Ca2+ exchanger, NCX-SQ1, expressed it in Xenopus oocytes, and characterized its regulatory and ion transport properties in giant excised membrane patches. The squid exchanger...
10.
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma
Huang C, Feng S, Hilgemann D
Nature
. 1998 Mar;
391(6669):803-6.
PMID: 9486652
Inward rectifier K+ channels, which modulate electrical activity in many cell types, are regulated by protein kinases, guanine-nucleotide-binding proteins (G proteins) and probably actin cytoskeleton. Generation of phosphatidylinositol 4,5-bisphosphate (PIP2)...